Transcription elongation factor SPT6 (SPT6) is a 1451-residue protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c). This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P23615.
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The mean pLDDT of this model is 79.9 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 52% |
| 70 to 90 | Confident: backbone generally right | 24% |
| 50 to 70 | Low: treat with caution | 8% |
| Below 50 | Very low: often disordered regions | 16% |
What pLDDT means and how to read it
Histone H3-H4 chaperone that plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression. Essential for viability
Interacts with CTR9
Nucleus, Chromosome
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 5VKO | X-ray | 1.8 Å | A=1247-1451 |
| 3PSK | X-ray | 2.1 Å | A/B/C/D=1247-1451 |
| 3OAK | X-ray | 2.15 Å | C/D=239-263 |
| 5VKL | X-ray | 2.2 Å | A=1247-1451 |
| 3PSF | X-ray | 2.59 Å | A=235-1259 |
| 3PSJ | X-ray | 2.7 Å | A=1247-1451 |
| 3PSI | X-ray | 3.3 Å | A=239-1451 |
| 7O3D | EM | 3.71 Å | A=298-1451 |
| 7O6B | EM | 3.88 Å | A=298-1451 |
| 2L3T | NMR | A=1250-1440 |
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