5-hydroxytryptamine receptor 3A (Htr3a) is a 489-residue protein from Mus musculus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P23979.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 80.9 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 52% |
| 70 to 90 | Confident: backbone generally right | 26% |
| 50 to 70 | Low: treat with caution | 4% |
| Below 50 | Very low: often disordered regions | 17% |
What pLDDT means and how to read it
Forms serotonin (5-hydroxytryptamine/5-HT3)-activated cation-selective channel complexes, which when activated cause fast, depolarizing responses in neurons
Forms homopentameric as well as heteropentameric serotonin-activated cation-selective channel complexes with HTR3B or HTR3C or HTR3D or HTR3E. The homomeric complex is functional but exhibits low conductance with modified voltage dependence, and decreased agonist and antagonist affinity. Heteropentameric complexes display properties which resemble that of neuronal serotonin-activated channels in…
Postsynaptic cell membrane, Cell membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 8FRX | EM | 2.7 Å | A/B/C/D/E=28-489 |
| 8FRZ | EM | 2.75 Å | A/B/C/D/E=28-489 |
| 8FSB | EM | 2.75 Å | A/B/C/D/E=28-489 |
| 6Y5A | EM | 2.8 Å | A/B/C/D/E=33-303, A/B/C/D/E=305-489 |
| 6Y1Z | EM | 2.82 Å | A/B/C/D/E=21-489 |
| 6NP0 | EM | 2.92 Å | A/B/C/D/E=1-489 |
| 6W1J | EM | 2.92 Å | A/B/C/D/E=34-489 |
| 8FRW | EM | 2.92 Å | A/B/C/D/E=28-489 |
| 8CC7 | EM | 3.0 Å | A/B/C/D/E=33-303, A/B/C/D/E=305-487 |
| 8AW2 | EM | 3.01 Å | A/B/C/D/E=33-303, A/B/C/D/E=305-487 |
| 6W1M | EM | 3.06 Å | A/B/C/D/E=34-489 |
| 6Y5B | EM | 3.1 Å | A/B/C/D/E=33-303, A/B/C/D/E=305-489 |
| 6HIQ | EM | 3.2 Å | A/B/C/D/E=36-487 |
| 6Y59 | EM | 3.2 Å | A/B/C/D/E=33-303, A/B/C/D/E=305-489 |
| 8CC6 | EM | 3.2 Å | A/B/C/D/E=33-303, A/B/C/D/E=305-487 |
| 6DG7 | EM | 3.32 Å | A/B/C/D/E=35-489 |
| 6W1Y | EM | 3.35 Å | A/B/C/D/E=34-489 |
| 4PIR | X-ray | 3.5 Å | A/B/C/D/E=33-487 |
| 8C20 | EM | 3.5 Å | A/B/C/D=33-303, A/B/C/D=305-489 |
| 8C21 | EM | 3.6 Å | A/B/C/D=33-303, A/B/C/D=305-489 |
Showing 20 of 29 experimental structures (best resolution first).
MolViewer loads the AlphaFold model straight from AlphaFold DB into your browser. Show it as a cartoon, color by pLDDT, measure distances and angles, and load a PDB structure next to it to compare.