Kelch repeat and BTB domain-containing protein A55 (KBTB1) is a 564-residue protein from Vaccinia virus. This is its AlphaFold structure prediction, created 3 Jul 2025. UniProt accession: P24768.
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The mean pLDDT of this model is 90.7 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 71% |
| 70 to 90 | Confident: backbone generally right | 24% |
| 50 to 70 | Low: treat with caution | 4% |
| Below 50 | Very low: often disordered regions | 0% |
What pLDDT means and how to read it
Substrate-specific adapter of CUL3-containing E3 ubiquitin-protein ligases which mediate the ubiquitination and subsequent proteasomal degradation of host target proteins (PubMed:30819806). Additionally, specifically inhibits NF-kappa-B signaling by preventing host RELA nuclear translocation, through targeting the host importin KPNA2 in a Kelch domain-dependent, but CUL3-independent manner (PubMed:30814284). In turn, inhibits CD8+ T-cell proliferation and activation in the acute phase of infection
Homodimer (PubMed:16690916). Interacts (via BTB domain) with host CUL3 (PubMed:30819806). Interacts with host IMA1/KPNA2 (PubMed:30814284)
Host cytoplasm
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6I2M | X-ray | 2.3 Å | A=1-250 |
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