Substance-P receptor (TACR1) is a 407-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P25103.
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The mean pLDDT of this model is 78.4 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 49% |
| 70 to 90 | Confident: backbone generally right | 24% |
| 50 to 70 | Low: treat with caution | 9% |
| Below 50 | Very low: often disordered regions | 18% |
What pLDDT means and how to read it
Receptor for the tachykinin substance P, also able to bind and respond to tachynins neurokinin A/substance K and neurokinin B/neuromedin-K (PubMed:1718267, PubMed:15452552). The rank order of affinity of this receptor to tachykinins is: substance P > neurokinin A/substance K > neurokinin B/neuromedin-K (PubMed:1718267). Substance P binding to its receptor triggers G protein-coupled receptor signaling via activation of phosphatidylinositol hydrolysis by phospholipase C. Substance P binding also triggers signaling via activation of adenylate cyclase activity which results in increased intracellular levels of cyclic AMP (cAMP) (By similarity)
Interacts with ARRB1
Cell membrane, Early endosome
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6HLP | X-ray | 2.2 Å | A=1-226, A=238-335 |
| 6HLO | X-ray | 2.4 Å | A=1-226, A=238-335 |
| 8U26 | EM | 2.5 Å | R=1-407 |
| 6J20 | X-ray | 2.7 Å | A=2-228, A=237-335 |
| 7P00 | EM | 2.71 Å | R=1-335 |
| 7P02 | EM | 2.87 Å | R=1-335 |
| 7RMG | EM | 3.0 Å | R=1-407 |
| 7RMH | EM | 3.1 Å | R=1-407 |
| 6J21 | X-ray | 3.2 Å | A=2-228, A=237-335 |
| 7RMI | EM | 3.2 Å | R=1-407 |
| 6HLL | X-ray | 3.27 Å | A=1-226, A=238-335 |
| 6E59 | X-ray | 3.4 Å | A=1-227, A=238-346 |
| 2KS9 | NMR | A=1-364 | |
| 2KSA | NMR | A=1-364 | |
| 2KSB | NMR | A=1-364 |
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