Atypical chemokine receptor 3 (ACKR3) is a 362-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P25106.
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The mean pLDDT of this model is 82.4 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 43% |
| 70 to 90 | Confident: backbone generally right | 38% |
| 50 to 70 | Low: treat with caution | 12% |
| Below 50 | Very low: often disordered regions | 7% |
What pLDDT means and how to read it
Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CXCL11 and CXCL12/SDF1 (PubMed:16107333, PubMed:19255243, PubMed:19380869, PubMed:20161793, PubMed:22300987). Chemokine binding does not activate G protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization and activation of MAPK…
Homodimer. Can form heterodimers with CXCR4; heterodimerization may regulate CXCR4 signaling activity. Interacts with ARRB1 and ARRB2
Cell membrane, Early endosome, Recycling endosome
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6K3F | X-ray | 2.3 Å | U/V/W/X/Y/Z=331-345 |
| 8TII | EM | 3.0 Å | R=2-362 |
| 7SK4 | EM | 3.3 Å | A=2-362 |
| 7SK7 | EM | 3.3 Å | A=2-362 |
| 7SK8 | EM | 3.3 Å | A=2-362 |
| 8VJ9 | EM | 3.3 Å | R=2-362 |
| 9E82 | EM | 3.4 Å | R=2-362 |
| 8TIO | EM | 3.6 Å | R=2-362 |
| 7SK9 | EM | 3.7 Å | A=2-362 |
| 7SK3 | EM | 3.8 Å | A=2-362 |
| 8TIL | EM | 3.8 Å | R=2-362 |
| 7SK5 | EM | 4.0 Å | A=2-362 |
| 7SK6 | EM | 4.0 Å | A=2-362 |
| 8TIN | EM | 4.0 Å | R=2-362 |
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