Moesin (Msn) is a 577-residue protein from Mus musculus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P26041.
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The mean pLDDT of this model is 86.1 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 68% |
| 70 to 90 | Confident: backbone generally right | 15% |
| 50 to 70 | Low: treat with caution | 10% |
| Below 50 | Very low: often disordered regions | 8% |
What pLDDT means and how to read it
Ezrin-radixin-moesin (ERM) family protein that connects the actin cytoskeleton to the plasma membrane and thereby regulates the structure and function of specific domains of the cell cortex. Tethers actin filaments by oscillating between a resting and an activated state providing transient interactions between moesin and the actin cytoskeleton (By similarity). Once phosphorylated on its C-terminal threonine, moesin is activated leading to interaction with F-actin and cytoskeletal rearrangement (By similarity). These rearrangements regulate many cellular processes, including cell shape determination, membrane transport, and signal transduction (By similarity). The role of moesin is…
In resting T-cells, part of a PAG1-NHERF1-MSN complex which is disrupted upon TCR activation (PubMed:11777944). Interacts with NHERF1 (PubMed:11777944). Interacts with PPP1R16B (By similarity). Interacts with SELPLG and SYK; these interactions mediate the activation of SYK by SELPLG (By similarity). Interacts with PDPN (via cytoplasmic domain); this interaction activates RHOA and promotes…
Cell membrane, Cytoplasm, cytoskeleton, Apical cell membrane, Cell projection, microvillus membrane, Cell projection, microvillus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4YL8 | X-ray | 1.5 Å | A=1-297 |
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