Adenylate cyclase type 2 (Adcy2) is a 1090-residue protein from Rattus norvegicus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P26769.
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The mean pLDDT of this model is 78.7 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 34% |
| 70 to 90 | Confident: backbone generally right | 42% |
| 50 to 70 | Low: treat with caution | 12% |
| Below 50 | Very low: often disordered regions | 12% |
What pLDDT means and how to read it
Catalyzes the formation of the signaling molecule cAMP in response to G protein signaling (PubMed:10427002, PubMed:11087399, PubMed:15591060, PubMed:16766715, PubMed:1719547, PubMed:19243146, PubMed:21596131, PubMed:22906005, PubMed:24363043, PubMed:7761832). Down-stream signaling cascades mediate changes in gene expression patterns and lead to increased IL6 production (PubMed:24363043). Functions in signaling cascades downstream of the muscarinic acetylcholine receptors (PubMed:22906005)
Interacts with RAF1 (By similarity). Interacts with GNAS (PubMed:10427002, PubMed:11087399, PubMed:15591060, PubMed:16766715, PubMed:19243146, PubMed:9417641). Interacts with the G protein beta and gamma subunit complex (PubMed:21596131)
Membrane, Cell membrane, Cytoplasm
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 1AB8 | X-ray | 2.2 Å | A/B=871-1090 |
| 1AZS | X-ray | 2.3 Å | B=870-1081 |
| 1CUL | X-ray | 2.4 Å | B=874-1081 |
| 1CS4 | X-ray | 2.5 Å | B=870-1081 |
| 3C14 | X-ray | 2.68 Å | B=870-1081 |
| 3C15 | X-ray | 2.78 Å | B=870-1081 |
| 1CJT | X-ray | 2.8 Å | B=870-1081 |
| 1CJU | X-ray | 2.8 Å | B=870-1081 |
| 1TL7 | X-ray | 2.8 Å | B=870-1081 |
| 3C16 | X-ray | 2.87 Å | B=870-1081 |
| 1U0H | X-ray | 2.9 Å | B=870-1081 |
| 2GVD | X-ray | 2.9 Å | B=870-1081 |
| 1CJK | X-ray | 3.0 Å | B=870-1081 |
| 1CJV | X-ray | 3.0 Å | B=870-1081 |
| 3MAA | X-ray | 3.0 Å | B=870-1081 |
| 3G82 | X-ray | 3.11 Å | B=870-1081 |
| 2GVZ | X-ray | 3.27 Å | B=870-1081 |
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