Kinesin-like protein KIF3A (Kif3a) is a 701-residue protein from Mus musculus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P28741.
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The mean pLDDT of this model is 75.3 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 22% |
| 70 to 90 | Confident: backbone generally right | 51% |
| 50 to 70 | Low: treat with caution | 10% |
| Below 50 | Very low: often disordered regions | 17% |
What pLDDT means and how to read it
Microtubule-based anterograde translocator for membranous organelles, such as primary cilium and centriole (PubMed:18497258, PubMed:21670265, PubMed:23386061, PubMed:7559760). Shows a plus end-directed microtubule sliding activity in vitro (PubMed:7559760). Plays a role in primary cilia formation, probably by mediating transport of proteins into primary cilia (PubMed:18497258, PubMed:21670265, PubMed:39138140). Mediates smoothened (SMO) translocation into primary cilia in response to hedgehog morphogens (PubMed:18497258, PubMed:39138140). Plays a role in centriole cohesion and subdistal appendage organization and function (PubMed:23386061). Regulates the formation of the subdistal…
Heterodimer of KIF3A and KIF3B (PubMed:7559760). Interacts with CIMAP3 (PubMed:20643351). Interacts with CLN3 (By similarity). Interacts with DCTN1 (PubMed:23386061). Interacts with FLCN (By similarity). Interacts with AP3B1 (By similarity)
Cytoplasm, cytoskeleton, Cell projection, cilium, Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 5JX1 | X-ray | 1.67 Å | A=352-376 |
| 5JVR | X-ray | 2.1 Å | A/B/C/D/E/F/G/H=352-359 |
| 9W9H | EM | 2.83 Å | A=481-701 |
| 9W9I | EM | 2.9 Å | A=536-701 |
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