9W9H: Mouse kinesin-2 tail

Cryo-EM structure of the mouse kinesin-2 tail in complex with KAP3 adaptor. Determined by electron microscopy at 2.83 Å resolution. Released 1 Oct 2025.

Method
Electron microscopy
Resolution
2.83 Å
Organism
Mus musculus
Chains
3
Atoms
6,085
Mol. weight
139.79 kDa
Released
1 Oct 2025

Explore 9W9H in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

9W9H contains 53 α-helices and 10 β-strands across 3 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 5 helices, 3 β-strands

ElementResiduesLengthSheet
α-helix581-59717
α-helix600-6089
β-strand610-61341
β-strand618-62141
α-helix624-6263
α-helix628-6347
α-helix651-6533
β-strand65512
Chain B: 6 helices, 3 β-strands
ElementResiduesLengthSheet
α-helix575-58915
α-helix593-6019
β-strand604-60633
β-strand611-61333
α-helix625-6295
α-helix641-6499
α-helix653-6553
α-helix667-6704
β-strand67314
Chain C: 42 helices, 4 β-strands
ElementResiduesLengthSheet
α-helix140-1434
α-helix149-16012
α-helix166-1716
α-helix176-18510
α-helix193-1953
α-helix201-2055
β-strand20714
α-helix208-2103
α-helix211-2166
α-helix219-24325
β-strand25415
β-strand25715
α-helix259-28931
α-helix293-3008
α-helix304-3118
α-helix317-33014
β-strand33312
α-helix334-3429
α-helix346-3494
α-helix358-37114
α-helix375-3839
α-helix386-3927
α-helix400-41112
α-helix414-4163
α-helix418-4203
α-helix427-4359
α-helix443-45210
α-helix456-4627
α-helix468-47710
α-helix481-49111
α-helix496-4994
α-helix502-5043
α-helix505-5128
α-helix519-52911
α-helix538-5447
α-helix547-5537
α-helix562-57514
α-helix582-5887
α-helix590-60011
α-helix605-61915
α-helix624-6263
α-helix627-6315
α-helix634-6407
α-helix647-66317
α-helix665-67915
α-helix681-6855

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Kinesin-like protein KIF3AAprotein233Mus musculusP28741 (AlphaFold model)
Kinesin-like protein KIF3BBprotein273Mus musculusQ61771 (AlphaFold model)
Kinesin-associated protein 3Cprotein693Mus musculusP70188 (AlphaFold model)
Sequence of entity 1 (A), FASTA
>9W9H_1 Kinesin-like protein KIF3A (chains A)
MGSSHHHHHHSQVIVGGVDLLAKAEEQEKLLEESNMELEERRRRAEQLRKELEEKEQERL
DIEEKYTSLQEEAQGKTKKLKKVWTMLMAAKSEMADLQQEHQREIEGLLENIRQLSRELR
LQMLIIDNFIPQDYQEMIENYVHWNEDIGEWQLKCVAYTGNNMRKQTPVPDKKERDPFEV
DLSHVYLAYTEESLRQSLMKLERPRTSKGKARPKMGRRKRSAKPETVIDSLLQ
Sequence of entity 2 (B), FASTA
>9W9H_2 Kinesin-like protein KIF3B (chains B)
LVGGKNIVDHTNEQQKILEQKRQEIAEQKRREREIQQQMESRDEETLELKETYTSLQQEV
DIKTKKLKKLFSKLQAVKAEIHDLQEEHIKERQELEQTQNELTRELKLKHLIIENFIPLE
EKNKIMNRSFFDDEEDHWKLHPITRLENQQMMKRPVSAVGYKRPLSQHARMSMMIRPEPR
YRAENIMLLELDMPSRTTRDYEGPAISPKVQAALDAALQDEDEIQVDASSFESTASRKPK
ARPKSGRKSGSSSSSSGNPASQFYPQSRGLVPK
Sequence of entity 3 (C), FASTA
>9W9H_3 Kinesin-associated protein 3 (chains C)
MQGEDARYLKRKVKGGNIDVHPSEKALIVQYEVEATILGEMGDPMLGERKECQKIIRLKS
LNANTDITSLARKVVEECKLIHPSKLSEVEQLLYYLQNRRDSLPGKEKKEKSSKPKDPPP
FEGMEIDEVANINDMDEYIELLYEDIPDKVRGSALILQLARNPDNLEELLLNETALGALA
RVLREDWKQSVELATNIIYIFFCFSSFSHFHGLITHYKIGALCMNIIDHELKRHELWQEE
LSKKKKAVDEDLENQTLRKDYDKTFKKYQGLVVKQEQLLRVALYLLLNLAEDTRTELKMR
NKNIVHMLVKALDRDNFELLILVVSFLKKLSIFMENKNDMVEMDIVEKLVKMIPCEHEDL
LNITLRLLLNLSFDTGLRNKMVQVGLLPKLTALLGNENYKQIAMCVLYHISMDDRFKSMF
AYTDCIPQLMKMLFECSDERIDLELISFCINLAANKRNVQLICEGNGLKMLMKRALKLKD
PLLMKMIRNISQHDGPTKNLFIDYVGDLAAQISSDEEEEFVIECLGTLANLTIPDLDWEL
VLKEYKLVPFLKDKLKPGAAEDDLVLEVVIMIGTVSMDDSCAALLAKSGIIPALIELLNA
QQEDDEFVCQIIYVFYQMVFHQATRDVIIKETQAPAYLIDLMHDKNNEIRKVCDNTLDII
AEYDEEWAKKIQSEKFRWHNSQWLEMVESRQLD

Primary citation

The hook-like adaptor and cargo-binding (HAC) domain in the kinesin-2 tail enables adaptor assembly and cargo recognition. Jiang, X., Danev, R., Ichinose, S. et al. Sci Adv (2025) 11:eady5861-eady5861. DOI 10.1126/sciadv.ady5861 · PubMed

Other PDB entries of the same protein (UniProt P28741 (AlphaFold model), which also has an AlphaFold model), best resolution first:

Browse structure collections

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