Synaptotagmin-2 (Syt2) is a 422-residue protein from Rattus norvegicus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P29101.
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The mean pLDDT of this model is 80.1 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 55% |
| 70 to 90 | Confident: backbone generally right | 19% |
| 50 to 70 | Low: treat with caution | 7% |
| Below 50 | Very low: often disordered regions | 19% |
What pLDDT means and how to read it
Exhibits calcium-dependent phospholipid and inositol polyphosphate binding properties. May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. Plays a role in dendrite formation by melanocytes
Homotetramer (Probable). Heterodimer; heterodimerizes with SYT1 in presence of calcium (PubMed:9867811). Interacts with SCAMP5 (By similarity). Interacts with STON2 (By similarity). Interacts with PRRT2 (By similarity)
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane, Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane, Cytoplasm
Compare the prediction with experimentally determined structures of the same protein:
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