Adenosine receptor A2a (ADORA2A) is a 412-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P29274.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 80.4 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 64% |
| 70 to 90 | Confident: backbone generally right | 10% |
| 50 to 70 | Low: treat with caution | 3% |
| Below 50 | Very low: often disordered regions | 24% |
What pLDDT means and how to read it
Receptor for adenosine (By similarity). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (By similarity)
Interacts (via cytoplasmic C-terminal domain) with USP4; the interaction is direct (PubMed:16339847). May interact with DRD4 (PubMed:18832607). Interacts with NECAB2 (PubMed:17689978). Interacts (via cytoplasmic C-terminal domain) with GAS2L2; interaction enhances receptor-mediated adenylyl cyclase activity (By similarity)
Cell membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 5NM4 | X-ray | 1.7 Å | A=2-208, A=219-317 |
| 5IU4 | X-ray | 1.72 Å | A=2-208, A=219-318 |
| 9H37 | X-ray | 1.72 Å | A=2-317 |
| 9H2X | X-ray | 1.75 Å | A=2-317 |
| 4EIY | X-ray | 1.8 Å | A=2-208, A=219-316 |
| 6LPJ | X-ray | 1.8 Å | A=2-208, A=219-316 |
| 6LPK | X-ray | 1.8 Å | A=2-208, A=219-316 |
| 6PS7 | X-ray | 1.85 Å | A=2-208, A=219-316 |
| 5OLG | X-ray | 1.87 Å | A=2-208, A=219-317 |
| 5IU7 | X-ray | 1.9 Å | A=2-208, A=219-315 |
| 5K2C | X-ray | 1.9 Å | A=2-208, A=219-316 |
| 5K2D | X-ray | 1.9 Å | A=2-208, A=219-316 |
| 5OLZ | X-ray | 1.9 Å | A=2-208, A=219-317 |
| 6ZDR | X-ray | 1.92 Å | A=2-208, A=219-317 |
| 8RW0 | X-ray | 1.94 Å | A=2-317 |
| 5NM2 | X-ray | 1.95 Å | A=2-208, A=219-317 |
| 5IU8 | X-ray | 2.0 Å | A=2-208, A=219-315 |
| 5MZJ | X-ray | 2.0 Å | A=2-208, A=219-318 |
| 5OLV | X-ray | 2.0 Å | A=2-208, A=219-317 |
| 5OM4 | X-ray | 2.0 Å | A=2-208, A=219-317 |
Showing 20 of 99 experimental structures (best resolution first).
MolViewer loads the AlphaFold model straight from AlphaFold DB into your browser. Show it as a cartoon, color by pLDDT, measure distances and angles, and load a PDB structure next to it to compare.