Non-receptor tyrosine-protein kinase TYK2 (TYK2) is a 1187-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P29597.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 81.8 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 51% |
| 70 to 90 | Confident: backbone generally right | 32% |
| 50 to 70 | Low: treat with caution | 4% |
| Below 50 | Very low: often disordered regions | 13% |
What pLDDT means and how to read it
Non-membrane spanning protein tyrosine kinase involved in numerous cytokines and interferons signaling, which regulates cell growth, development, cell migration, innate and adaptive immunity (PubMed:10542297, PubMed:10995743, PubMed:7657660, PubMed:7813427, PubMed:8232552). Plays both structural and catalytic roles in numerous interleukins and interferons (IFN-alpha/beta) signaling (PubMed:10542297). Associates with heterodimeric cytokine receptor complexes and activates STAT family members including STAT1, STAT3, STAT4 or STAT6 (PubMed:10542297, PubMed:7638186). The heterodimeric cytokine receptor complexes are composed of (1) a TYK2-associated receptor chain (IFNAR1, IL12RB1, IL10RB or…
Interacts (via FERM domain) with JAKMIP1 (PubMed:15277531, PubMed:20478313). Interacts with PIK3R1; this interaction is important for cell migration (PubMed:10995743). Interacts with MPL/TPOR (PubMed:15899890)
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3LXP | X-ray | 1.65 Å | A=888-1182 |
| 8S99 | X-ray | 1.71 Å | A/B/C=575-869 |
| 4WOV | X-ray | 1.8 Å | A/B=575-869 |
| 8S9A | X-ray | 1.83 Å | A/B/C=575-869 |
| 8S98 | X-ray | 1.87 Å | A/B/C=575-869 |
| 5C03 | X-ray | 1.9 Å | A/B=556-871 |
| 5TKD | X-ray | 1.92 Å | A/B=575-869 |
| 6NZE | X-ray | 1.96 Å | A/B=575-869 |
| 8TB6 | X-ray | 1.96 Å | A/B=566-870 |
| 6AAM | X-ray | 1.98 Å | A=888-1182 |
| 4PO6 | X-ray | 1.99 Å | A=23-583 |
| 3NZ0 | X-ray | 2.0 Å | A=885-1176 |
| 4GIH | X-ray | 2.0 Å | A=885-1176 |
| 6DBK | X-ray | 2.0 Å | A=888-1182 |
| 4GVJ | X-ray | 2.03 Å | A=885-1176 |
| 7UYU | X-ray | 2.05 Å | A=889-1177 |
| 6VNS | X-ray | 2.09 Å | A=888-1182 |
| 6NZQ | X-ray | 2.11 Å | A/B=575-869 |
| 7AX4 | X-ray | 2.12 Å | A/B=575-869 |
| 7UYT | X-ray | 2.14 Å | A=889-1177 |
Showing 20 of 52 experimental structures (best resolution first).
MolViewer loads the AlphaFold model straight from AlphaFold DB into your browser. Show it as a cartoon, color by pLDDT, measure distances and angles, and load a PDB structure next to it to compare.