Oxytocin receptor (OXTR) is a 389-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P30559.
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The mean pLDDT of this model is 78.6 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 52% |
| 70 to 90 | Confident: backbone generally right | 20% |
| 50 to 70 | Low: treat with caution | 11% |
| Below 50 | Very low: often disordered regions | 17% |
What pLDDT means and how to read it
G protein-coupled receptor for oxytocin (OXT), a neuropeptide hormone released by the posterior pituitary gland that plays a key role in social behavior and other biological processes, such as milk ejection (PubMed:11923477, PubMed:22069312, PubMed:32832646, PubMed:35104164, PubMed:35241813, PubMed:35851571). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as phospholipase C (PubMed:22069312, PubMed:32832646, PubMed:35104164, PubMed:35241813, PubMed:35851571). OXTR is mainly coupled to G(q) G proteins and mediates production of diacylglycerol (DAG) and inositol…
Interacts (when phosphorylated following prolonged stimulation by oxytocin) with ARRB1 and/or ARRB2, leading to receptor desensitization
Cell membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7RYC | EM | 2.9 Å | O=1-389 |
| 6TPK | X-ray | 3.2 Å | A=35-356 |
| 7QVM | EM | 3.25 Å | R=1-359 |
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