Adenylate cyclase type 5 (ADCY5) is a 1265-residue protein from Canis lupus familiaris. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P30803.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 73.1 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 28% |
| 70 to 90 | Confident: backbone generally right | 43% |
| 50 to 70 | Low: treat with caution | 10% |
| Below 50 | Very low: often disordered regions | 20% |
What pLDDT means and how to read it
Catalyzes the formation of the signaling molecule cAMP in response to G protein signaling (PubMed:10427002, PubMed:11087399, PubMed:15591060, PubMed:1618857, PubMed:16766715, PubMed:19243146, PubMed:8119955, PubMed:8428899, PubMed:9748257). Mediates signaling downstream of ADRB1. Regulates the increase of free cytosolic Ca(2+) in response to increased blood glucose levels and contributes to the regulation of Ca(2+)-dependent insulin secretion (By similarity)
Interacts with GNAS (PubMed:10427002, PubMed:11087399, PubMed:15591060, PubMed:16766715, PubMed:19243146, PubMed:9417641). Interacts with GNB1 and GNG2 (By similarity). Part of a complex containing AKAP5, ADCY6, PDE4C and PKD2 (By similarity). Interacts with RAF1 (By similarity)
Cell membrane, Cell projection, cilium
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 1AZS | X-ray | 2.3 Å | A=441-656 |
| 1CUL | X-ray | 2.4 Å | A=445-661 |
| 1CS4 | X-ray | 2.5 Å | A=441-661 |
| 3C14 | X-ray | 2.68 Å | A=444-661 |
| 3C15 | X-ray | 2.78 Å | A=444-661 |
| 1CJT | X-ray | 2.8 Å | A=445-661 |
| 1CJU | X-ray | 2.8 Å | A=445-661 |
| 1TL7 | X-ray | 2.8 Å | A=445-661 |
| 3C16 | X-ray | 2.87 Å | A=444-661 |
| 1U0H | X-ray | 2.9 Å | A=442-661 |
| 2GVD | X-ray | 2.9 Å | A=444-661 |
| 1CJK | X-ray | 3.0 Å | A=445-661 |
| 1CJV | X-ray | 3.0 Å | A=445-661 |
| 3MAA | X-ray | 3.0 Å | A=444-661 |
| 3G82 | X-ray | 3.11 Å | A=444-661 |
| 2GVZ | X-ray | 3.27 Å | A=444-661 |
MolViewer loads the AlphaFold model straight from AlphaFold DB into your browser. Show it as a cartoon, color by pLDDT, measure distances and angles, and load a PDB structure next to it to compare.