Gamma-aminobutyric acid receptor subunit alpha-5 (GABRA5) is a 462-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P31644.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 81.0 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 60% |
| 70 to 90 | Confident: backbone generally right | 19% |
| 50 to 70 | Low: treat with caution | 4% |
| Below 50 | Very low: often disordered regions | 18% |
What pLDDT means and how to read it
Alpha subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed:14993607, PubMed:29961870, PubMed:30140029, PubMed:31056671). GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s) (PubMed:30140029). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (PubMed:14993607, PubMed:30140029). GABAARs containing alpha-5/GABRA5 subunits are mainly…
Heteropentamer, formed by a combination of alpha (GABRA1-6), beta (GABRB1-3), gamma (GABRG1-3), delta (GABRD), epsilon (GABRE), rho (GABRR1-3), pi (GABRP) and theta (GABRQ) chains, each subunit exhibiting distinct physiological and pharmacological properties
Postsynaptic cell membrane, Cell membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 8BHG | X-ray | 2.39 Å | A/C/D/E=32-451 |
| 8BHB | EM | 2.54 Å | A/B/C/D/E=32-315, A/B/C/D/E=424-450 |
| 8BGI | X-ray | 2.56 Å | A/B/C/D/E=32-346, A/B/C/D/E=424-450 |
| 8BHA | EM | 2.67 Å | A/B/C/D/E=32-315, A/B/C/D/E=424-450 |
| 8BHI | EM | 2.67 Å | A/B/C/D/E=32-315, A/B/C/D/E=424-450 |
| 8BHO | EM | 2.93 Å | A/B/C/D/E=32-315, A/B/C/D/E=424-450 |
| 8BHM | EM | 2.95 Å | A/B/C/D/E=32-315, A/B/C/D/E=424-450 |
| 9HNS | EM | 3.1 Å | A/D=33-346, A/D=421-462 |
| 9RL5 | EM | 3.1 Å | A/D=23-346, A/D=421-462 |
| 9RPB | EM | 3.1 Å | A/D=33-346, A/D=421-462 |
| 9HAA | EM | 3.14 Å | A/D=33-346, A/D=421-462 |
| 9HNR | EM | 3.17 Å | A=33-346, A=421-462 |
| 5O8F | X-ray | 3.2 Å | A/B/C/D/E=261-346, A/B/C/D/E=424-462 |
| 8BEJ | EM | 3.24 Å | A/B/C/D/E=32-345, A/B/C/D/E=424-450 |
| 8BHS | EM | 3.24 Å | A/B/C/D/E=32-346, A/B/C/D/E=424-450 |
| 5OJM | X-ray | 3.3 Å | A/B/C/D/E=261-346, A/B/C/D/E=424-462 |
| 8BHK | EM | 3.3 Å | A/B/C/D/E=32-315, A/B/C/D/E=424-450 |
| 8BHQ | EM | 3.3 Å | A/B/C/D/E=32-315, A/B/C/D/E=424-450 |
| 9HNT | EM | 3.32 Å | A/D=33-346, A/D=421-462 |
| 9HUM | EM | 3.35 Å | A/D=33-345, A/D=421-462 |
Showing 20 of 23 experimental structures (best resolution first).
MolViewer loads the AlphaFold model straight from AlphaFold DB into your browser. Show it as a cartoon, color by pLDDT, measure distances and angles, and load a PDB structure next to it to compare.