14-3-3 protein beta/alpha (YWHAB) is a 246-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P31946.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 93.4 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 87% |
| 70 to 90 | Confident: backbone generally right | 8% |
| 50 to 70 | Low: treat with caution | 1% |
| Below 50 | Very low: often disordered regions | 4% |
What pLDDT means and how to read it
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2. Negative regulator of signaling cascades that mediate activation of MAP kinases via AKAP13
Homodimer (PubMed:17717073). Forms heterodimers with SFN, YWHAG or YWHAQ (By similarity). Interacts with SAMSN1 and PRKCE (By similarity). Interacts with AKAP13 (PubMed:21224381). Interacts with SSH1 and TORC2/CRTC2 (PubMed:15159416, PubMed:15454081). Interacts with ABL1; the interaction results in cytoplasmic location of ABL1 and inhibition of cABL-mediated apoptosis (PubMed:15696159).…
Cytoplasm, Melanosome, Vacuole membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 8EQ8 | X-ray | 1.5 Å | A/B=1-239 |
| 5N10 | X-ray | 1.6 Å | A/B=1-246 |
| 6HEP | X-ray | 1.86 Å | A/B/C/D=1-232 |
| 8EQH | X-ray | 1.9 Å | A/B=1-239 |
| 6A5Q | X-ray | 2.0 Å | A/B/C=1-246 |
| 6YGJ | X-ray | 2.07 Å | A=4-232, F=2-232 |
| 4DNK | X-ray | 2.2 Å | A/B=1-246 |
| 6GN8 | X-ray | 2.34 Å | A/B=1-234 |
| 2BQ0 | X-ray | 2.5 Å | A/B=1-240 |
| 6GNK | X-ray | 2.55 Å | A/B=1-234 |
| 9GCP | X-ray | 2.59 Å | A/C/E/G=3-232 |
| 2C23 | X-ray | 2.65 Å | A=1-240 |
| 6BYK | X-ray | 3.0 Å | A/B/C/D=3-232 |
| 8DP5 | EM | 3.1 Å | C=1-246 |
| 6GN0 | X-ray | 3.24 Å | A/B/C/D=1-239 |
| 6GNJ | X-ray | 3.24 Å | A/B=1-234 |
| 6GNN | X-ray | 3.79 Å | A=1-239 |
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