Vasoactive intestinal polypeptide receptor 1 (VIPR1) is a 457-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P32241.
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The mean pLDDT of this model is 76.0 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 30% |
| 70 to 90 | Confident: backbone generally right | 37% |
| 50 to 70 | Low: treat with caution | 18% |
| Below 50 | Very low: often disordered regions | 15% |
What pLDDT means and how to read it
G protein-coupled receptor activated by the neuropeptides vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating polypeptide (ADCYAP1/PACAP) (PubMed:35477937, PubMed:36385145, PubMed:8179610). Binds VIP and both PACAP27 and PACAP38 bioactive peptides with the following order of ligand affinity VIP = PACAP27 > PACAP38 (PubMed:35477937, PubMed:8179610). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. Activates cAMP-dependent pathway (PubMed:35477937, PubMed:36385145, PubMed:8179610)
Interacts with ADCYAP1/PACAP; activated by both PACAP27 and PACAP38 neuropeptides (PubMed:36385145). Interacts with VIP; the interaction results in VIPR1 activation (PubMed:36385145)
Cell membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 5IB2 | X-ray | 1.44 Å | C=400-408 |
| 1OGT | X-ray | 1.47 Å | C=400-408 |
| 5DEF | X-ray | 1.6 Å | C=400-408 |
| 3B6S | X-ray | 1.8 Å | C=400-408 |
| 7ALO | X-ray | 1.8 Å | C/F=400-408 |
| 5DEG | X-ray | 1.83 Å | C=400-408 |
| 3B3I | X-ray | 1.86 Å | C=400-408 |
| 5IB1 | X-ray | 1.91 Å | C=400-408 |
| 5IB3 | X-ray | 1.91 Å | C=400-408 |
| 3HCV | X-ray | 1.95 Å | C=400-408 |
| 5IB4 | X-ray | 1.95 Å | C=400-408 |
| 3DTX | X-ray | 2.1 Å | C=400-408 |
| 1OF2 | X-ray | 2.2 Å | C=400-408 |
| 8E3Y | EM | 2.3 Å | R=28-457 |
| 5IB5 | X-ray | 2.49 Å | C/F=400-408 |
| 8E3Z | EM | 2.7 Å | R=28-457 |
| 6VN7 | EM | 3.2 Å | R=31-437 |
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