Neuronal acetylcholine receptor subunit alpha-3 (CHRNA3) is a 505-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P32297.
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The mean pLDDT of this model is 81.1 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 60% |
| 70 to 90 | Confident: backbone generally right | 16% |
| 50 to 70 | Low: treat with caution | 7% |
| Below 50 | Very low: often disordered regions | 16% |
What pLDDT means and how to read it
Component of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability among other activities. nAChRs are excitatory neurotrasnmitter receptors formed by a collection of nAChR subunits known to mediate synaptic transmission in the nervous system and the neuromuscular junction. Each nAchR subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, cation permeability, and binding to allosteric modulators (PubMed:31488329, PubMed:31708116). CHRNA3 forms heteropentameric neuronal acetylcholine receptors with CHRNB2 and CHRNB4, with…
Neuronal AChR is composed of two different types of subunits: alpha and beta. CHRNA3/Alpha-3 subunit can be combined to CHRNA5/alpha-5, CHRNB2/beta-2 CHRNB3/beta-3 or CHRNB4/beta-4 to give rise to functional receptors (PubMed:20881005, PubMed:31488329, PubMed:8663494). Forms stoichiometries such as (CHRNA3)2:(CHRNB4)3 or (CHRNA3:CHRNB4)2:CHRNB3 (PubMed:11118490). Part of a complex composed of…
Synaptic cell membrane, Cell membrane, Endoplasmic reticulum, Golgi apparatus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4ZK4 | X-ray | 1.9 Å | A/B/C/D/E=215-230 |
| 5TVC | X-ray | 1.93 Å | A/B/C/D/E=215-230 |
| 5SYO | X-ray | 2.0 Å | A/B/C/D/E=215-230 |
| 6PV7 | EM | 3.34 Å | A/D=32-378, A/D=434-505 |
| 6PV8 | EM | 3.87 Å | A/D=32-378, A/D=434-505 |
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