Importin subunit beta-3 (PSE1) is a 1089-residue protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c). This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P32337.
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The mean pLDDT of this model is 93.4 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 84% |
| 70 to 90 | Confident: backbone generally right | 14% |
| 50 to 70 | Low: treat with caution | 2% |
| Below 50 | Very low: often disordered regions | 1% |
What pLDDT means and how to read it
Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for classical and arginine/glycine-rich nuclear localization signals (cNLS and rg-NLS) in cargo substrates (PubMed:15367670). Its predominant cargo substrate seems to be ribosomal proteins and ribosome biogenesis trans- and cis-acting factors (PubMed:15367670, PubMed:9182759, PubMed:9321403). Required for nuclear transport of YAP1, NOP1 and SOF1 (PubMed:11274141, PubMed:15367670). Mediates the nuclear import of histones H3 and H4 (PubMed:11694505). Mediates docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to repeat-containing nucleoporins. The complex is…
Interacts with Ran (GSP1); interacts specifically with the GTP-bound form of Ran (GTP-Ran), protecting it from GTP hydrolysis and nucleotide exchange (PubMed:9321403). Interacts with RPL25; this interaction is dissociated by binding to Ran-GTP (PubMed:9321403). Interacts with YAP1; this interaction is dissociated by binding to Ran-GTP (PubMed:11274141). Interacts with NOP1; via its rg-NLS…
Cytoplasm, Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3W3W | X-ray | 2.2 Å | A=1-1089 |
| 4ZJ7 | X-ray | 2.4 Å | A=1-1089 |
| 3W3U | X-ray | 2.6 Å | A=1-1089 |
| 3W3Z | X-ray | 2.7 Å | A=1-1089 |
| 3W3Y | X-ray | 2.8 Å | A=1-1089 |
| 5H2V | X-ray | 2.8 Å | A=1-1089 |
| 3W3T | X-ray | 2.9 Å | A=1-1089 |
| 3W3X | X-ray | 2.9 Å | A=1-1089 |
| 3W3V | X-ray | 3.2 Å | A=1-1089 |
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