Polycomb complex protein BMI-1 (BMI1) is a 326-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P35226.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 76.8 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 52% |
| 70 to 90 | Confident: backbone generally right | 10% |
| 50 to 70 | Low: treat with caution | 13% |
| Below 50 | Very low: often disordered regions | 25% |
What pLDDT means and how to read it
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:15386022, PubMed:16359901, PubMed:16714294, PubMed:21772249, PubMed:25355358, PubMed:26151332, PubMed:27827373). The complex composed of RNF2, UB2D3 and BMI1 binds nucleosomes, and has activity only with nucleosomal histone H2A (PubMed:21772249, PubMed:25355358). In the PRC1-like complex,…
Component of a PRC1-like complex (PubMed:12167701, PubMed:15386022, PubMed:19636380, PubMed:21282530, PubMed:21772249, PubMed:25355358, PubMed:26151332). Identified in a PRC1-like HPRC-H complex with CBX2, CBX4, CBX8, PHC1, PHC2, PHC3 RING1 and RNF2 (PubMed:12167701). Interacts with RNF2/RING2 (PubMed:16714294, PubMed:21772249, PubMed:25355358). Interacts with RING1 (By similarity). Part of a…
Nucleus, Cytoplasm
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6WI7 | X-ray | 1.7 Å | A=1-104 |
| 2H0D | X-ray | 2.5 Å | A=5-101 |
| 5FR6 | X-ray | 2.51 Å | A=121-235 |
| 3RPG | X-ray | 2.65 Å | B=1-109 |
| 9DBY | EM | 2.8 Å | K=1-326 |
| 8PP7 | EM | 2.91 Å | K/M=1-326 |
| 9DGG | EM | 2.98 Å | K=1-326 |
| 8GRM | EM | 3.05 Å | M=2-102 |
| 6WI8 | X-ray | 3.09 Å | A/B=1-104 |
| 9DDE | EM | 3.2 Å | K=1-326 |
| 4R8P | X-ray | 3.28 Å | K/M=2-109 |
| 2NA1 | NMR | A=121-235 | |
| 7ND1 | NMR | H=4-104 |
MolViewer loads the AlphaFold model straight from AlphaFold DB into your browser. Show it as a cartoon, color by pLDDT, measure distances and angles, and load a PDB structure next to it to compare.