Somatostatin receptor type 5 (SSTR5) is a 364-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P35346.
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The mean pLDDT of this model is 81.3 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 62% |
| 70 to 90 | Confident: backbone generally right | 14% |
| 50 to 70 | Low: treat with caution | 5% |
| Below 50 | Very low: often disordered regions | 20% |
What pLDDT means and how to read it
Receptor for somatostatin 28 and to a lesser extent for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Increases cell growth inhibition activity of SSTR2 following heterodimerization
Heterodimer with SSTR2. Heterodimerization with SSTR2 increases cell growth inhibition activity of SSTR2
Cell membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 9W32 | EM | 2.59 Å | A/B=35-231, A/B=241-321 |
| 9W33 | EM | 2.69 Å | A/B=35-231, A/B=241-321 |
| 8X8L | EM | 2.7 Å | R=1-364 |
| 8X8N | EM | 2.9 Å | R=1-364 |
| 8ZBJ | EM | 2.94 Å | R=1-364 |
| 8ZCJ | EM | 3.09 Å | G=1-364 |
| 8ZBE | EM | 3.24 Å | A=1-364 |
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