Alpha-1A adrenergic receptor (ADRA1A) is a 466-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P35348.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 70.3 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 44% |
| 70 to 90 | Confident: backbone generally right | 17% |
| 50 to 70 | Low: treat with caution | 4% |
| Below 50 | Very low: often disordered regions | 35% |
What pLDDT means and how to read it
Alpha-1 adrenergic receptors are G protein-coupled receptors for catecholamines that signal through the G(q) family of G proteins, including G(q) and G(11). Upon activation, they stimulate the phosphatidylinositol-calcium second messenger pathway, leading to calcium release from intracellular stores and activation of protein kinase C (PubMed:37563160). ADRA1A binds the catecholamine ligands norepinephrine and epinephrine (PubMed:18802028, PubMed:37563160, PubMed:7815325, PubMed:8024574, PubMed:8183249, PubMed:8832064). Can also couple to G(14) protein (By similarity). Nuclear ADRA1A forms heterooligomers with ADRA1B to regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes…
Homo- and heterooligomer. Heterooligomerizes with ADRA1B homooligomers in cardiac myocytes (PubMed:22120526). Interacts with CAVIN4 (PubMed:24567387)
Nucleus membrane, Cell membrane, Cytoplasm, Membrane, caveola
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 8THK | EM | 2.6 Å | R=15-350 |
| 8HN1 | EM | 2.9 Å | A=1-371 |
| 7YM8 | EM | 2.92 Å | A=1-227, A=262-371 |
| 9M4Q | EM | 2.99 Å | A=19-341 |
| 8THL | EM | 3.1 Å | R=15-350 |
| 9M4T | EM | 3.19 Å | A=19-341 |
| 9IQV | EM | 3.3 Å | B=5-341 |
| 7YMJ | EM | 3.35 Å | A=1-234, A=276-371 |
| 7YMH | EM | 3.52 Å | A=1-227, A=262-371 |
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