H(+)/Cl(-) exchange transporter ClcA (clcA) is a 473-residue protein from Escherichia coli (strain K12). This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P37019.
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The mean pLDDT of this model is 95.6 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 92% |
| 70 to 90 | Confident: backbone generally right | 6% |
| 50 to 70 | Low: treat with caution | 2% |
| Below 50 | Very low: often disordered regions | 1% |
What pLDDT means and how to read it
Proton-coupled chloride transporter. Functions as antiport system and exchanges two chloride ions for 1 proton. Probably acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation, as part of the extreme acid resistance (XAR) response
Homodimer
Cell inner membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4ENE | X-ray | 2.4 Å | A/B=17-460 |
| 1OTS | X-ray | 2.51 Å | A/B=1-465 |
| 8GA1 | EM | 2.6 Å | A/B=1-461 |
| 8GA5 | EM | 2.6 Å | A/B=1-461 |
| 6V2J | X-ray | 2.62 Å | A=1-468 |
| 6ADB | X-ray | 2.69 Å | A/B=1-473 |
| 3DET | X-ray | 2.8 Å | A/B=1-473 |
| 4KKL | X-ray | 2.85 Å | A/B=17-460 |
| 4KK8 | X-ray | 2.86 Å | A/B=17-460 |
| 4KJQ | X-ray | 2.88 Å | A/B=17-460 |
| 3EJZ | X-ray | 2.9 Å | A/B=1-473 |
| 7CVT | X-ray | 2.9 Å | A/B=1-473 |
| 8GAH | EM | 2.9 Å | A/B=1-461 |
| 6AD7 | X-ray | 2.95 Å | A/B=1-473 |
| 4LOU | X-ray | 2.98 Å | A/B=17-460 |
| 1OTT | X-ray | 3.0 Å | A/B=1-465 |
| 4KK9 | X-ray | 3.0 Å | A/B=17-460 |
| 4KKA | X-ray | 3.0 Å | A/B=17-460 |
| 7CVS | X-ray | 3.01 Å | A/B=1-473 |
| 4KKB | X-ray | 3.02 Å | A/B=17-460 |
Showing 20 of 66 experimental structures (best resolution first).
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