RQC P-site tRNA stabilizing factor (rqcP) is a 86-residue protein from Bacillus subtilis (strain 168). This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P37557.
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The mean pLDDT of this model is 90.8 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 76% |
| 70 to 90 | Confident: backbone generally right | 23% |
| 50 to 70 | Low: treat with caution | 1% |
| Below 50 | Very low: often disordered regions | 0% |
What pLDDT means and how to read it
Key component of the ribosome quality control system (RQC), a ribosome-associated complex that mediates the extraction of incompletely synthesized nascent chains from stalled ribosomes and their subsequent degradation (PubMed:33259811, PubMed:33259810, PubMed:34255840). RqcH recruits Ala-charged tRNA, and with RqcP directs the elongation of stalled nascent chains on 50S ribosomal subunits, leading to non-templated C-terminal alanine extensions (Ala tail) (PubMed:33259811, PubMed:33259810, PubMed:34255840). The Ala tail promotes nascent chain degradation (PubMed:34255840). RqcP is associated with the translocation-like movement of the peptidyl-tRNA from the A-site into the P-site…
Associates with stalled 50S ribosomal subunits (PubMed:33259811, PubMed:33259810, PubMed:34255840). Binds to RqcH, 23S rRNA and the P-site tRNA (PubMed:33259811, PubMed:33259810, PubMed:34255840). Does not require RqcH for association with 50S subunits (PubMed:34255840). Crystallized 50S subunits are variously associated with an A/P-site tRNA with or without RqcH, as well as with P- and E-site…
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7AS8 | EM | 2.9 Å | 1=1-86 |
| 7AQC | EM | 2.99 Å | Y=1-86 |
| 7OPE | EM | 3.2 Å | 1=1-86 |
| 7ASA | EM | 3.5 Å | 1=1-86 |
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