Proteasome-interacting protein CIC1 (CIC1) is a 376-residue protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c). This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P38779.
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The mean pLDDT of this model is 80.3 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 40% |
| 70 to 90 | Confident: backbone generally right | 38% |
| 50 to 70 | Low: treat with caution | 12% |
| Below 50 | Very low: often disordered regions | 10% |
What pLDDT means and how to read it
An adapter protein that specifically links the 26S proteasome to its substrate CDC4 which is one of the substrate recognition subunits of the SCF E3 ubiquitin ligase complex. Required for turnover of cell cycle regulatory proteins CDC4 and GRR1. Required for synthesis and nuclear export of 60S ribosomal subunits. Required for vegetative growth
Interacts with CDC4, PRE4, PRE6, RPT1 and SCL1 as part of the fully assembled 26S proteasome. Interacts with pre-ribosomal particles constituent NOP7
Nucleus, nucleolus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7UOO | EM | 2.34 Å | K=1-376 |
| 7V08 | EM | 2.36 Å | K=1-376 |
| 7UQB | EM | 2.43 Å | K=1-376 |
| 7UQZ | EM | 2.44 Å | K=1-339 |
| 8V83 | EM | 2.53 Å | K=1-376 |
| 8V87 | EM | 2.66 Å | K=1-376 |
| 8V84 | EM | 2.7 Å | K=1-376 |
| 7U0H | EM | 2.76 Å | K=1-376 |
| 7R6Q | EM | 2.98 Å | K=1-376 |
| 7NAC | EM | 3.04 Å | K=1-376 |
| 7R7A | EM | 3.04 Å | K=1-376 |
| 3JCT | EM | 3.08 Å | K=1-376 |
| 7OHQ | EM | 3.1 Å | K=1-376 |
| 6EM3 | EM | 3.2 Å | K=1-376 |
| 6M62 | EM | 3.2 Å | K=1-376 |
| 7BTB | EM | 3.22 Å | K=1-376 |
| 6ELZ | EM | 3.3 Å | K=1-376 |
| 7OHX | EM | 3.3 Å | K=1-376 |
| 7OHW | EM | 3.5 Å | K=1-376 |
| 6EM1 | EM | 3.6 Å | K=1-376 |
Showing 20 of 32 experimental structures (best resolution first).
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