26S proteasome regulatory subunit RPN3 (RPN3) is a 523-residue protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c). This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P40016.
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The mean pLDDT of this model is 77.4 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 29% |
| 70 to 90 | Confident: backbone generally right | 42% |
| 50 to 70 | Low: treat with caution | 17% |
| Below 50 | Very low: often disordered regions | 11% |
What pLDDT means and how to read it
Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins
The 26S proteasome is composed of a core protease, known as the 20S proteasome, capped at one or both ends by the 19S regulatory complex (RC). The RC is composed of at least 18 different subunits in two subcomplexes, the base and the lid, which form the portions proximal and distal to the 20S proteolytic core, respectively (By similarity)
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3JCK | EM | 3.5 Å | A=131-523 |
| 9CGC | EM | 3.61 Å | S=1-523 |
| 6J2Q | EM | 3.8 Å | S=1-523 |
| 6J2X | EM | 3.8 Å | S=1-523 |
| 5MPD | EM | 4.1 Å | S=1-523 |
| 6FVT | EM | 4.1 Å | S=18-492 |
| 5WVK | EM | 4.2 Å | S=1-523 |
| 5MPE | EM | 4.5 Å | S=1-523 |
| 6FVU | EM | 4.5 Å | S=18-492 |
| 6FVW | EM | 4.5 Å | S=18-492 |
| 6J30 | EM | 4.5 Å | S=1-523 |
| 3JCP | EM | 4.6 Å | S=1-523 |
| 3JCO | EM | 4.8 Å | S=1-523 |
| 6FVX | EM | 4.9 Å | S=18-492 |
| 6FVV | EM | 5.4 Å | S=18-492 |
| 7QO5 | EM | 6.0 Å | S=1-523 |
| 6FVY | EM | 6.1 Å | S=18-492 |
| 7QO3 | EM | 6.1 Å | S=1-523 |
| 5WVI | EM | 6.3 Å | S=1-523 |
| 6J2C | EM | 7.0 Å | S=1-523 |
Showing 20 of 29 experimental structures (best resolution first).
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