Protein transport protein SEC24 (SEC24) is a 926-residue protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c). This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P40482.
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The mean pLDDT of this model is 87.2 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 77% |
| 70 to 90 | Confident: backbone generally right | 7% |
| 50 to 70 | Low: treat with caution | 3% |
| Below 50 | Very low: often disordered regions | 14% |
What pLDDT means and how to read it
Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules. SEC24 specifically recruits cargo proteins like BET1 or SYS1 to the COPII vesicles. The SEC23/24 complex is also involved in internalization of plasma membrane proteins like the maltose transporter
The COPII coat is composed of at least 7 proteins: the SEC23/24 complex, the SEC13/31 complex, SFB2, SFB3 and the protein SAR1. Interacts with BET1, EMP24, GRH1, SEC22, SED5 and SYS1
Cytoplasm, Cytoplasmic vesicle, COPII-coated vesicle membrane, Endoplasmic reticulum membrane, Golgi apparatus membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 1PCX | X-ray | 2.5 Å | A=117-926 |
| 1PD0 | X-ray | 2.6 Å | A=117-926 |
| 1PD1 | X-ray | 2.6 Å | A=117-926 |
| 1M2V | X-ray | 2.75 Å | B=1-926 |
| 8BSH | EM | 3.8 Å | C=1-926 |
| 6ZGA | EM | 4.6 Å | B/F=1-926 |
| 6GNI | EM | 4.9 Å | E=133-926 |
| 4BZI | EM | 23.0 Å | E/F/L/M/N/O=1-926 |
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