Leptin (LEP) is a 167-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P41159.
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The mean pLDDT of this model is 81.1 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 40% |
| 70 to 90 | Confident: backbone generally right | 29% |
| 50 to 70 | Low: treat with caution | 31% |
| Below 50 | Very low: often disordered regions | 0% |
What pLDDT means and how to read it
Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (PubMed:15899045, PubMed:17344214, PubMed:19688109). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, increases basal metabolism, influences reproductive function, regulates…
Interacts with SIGLEC6
Secreted
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 1AX8 | X-ray | 2.4 Å | A=22-167 |
| 9PUO | X-ray | 3.1 Å | C/F=22-167 |
| 8X85 | EM | 3.58 Å | C/D=1-167 |
| 7Z3Q | X-ray | 3.62 Å | A/C/E=22-167 |
| 8X81 | EM | 3.77 Å | D/E/F=1-167 |
| 8X80 | EM | 3.88 Å | D/E/F=1-167 |
| 8AVE | EM | 5.62 Å | A/C=22-167 |
| 8AVF | EM | 6.45 Å | A/C/E=22-167 |
| 8AVO | EM | 6.84 Å | A/C/E=22-167 |
| 8K6Z | NMR | A=22-167 |
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