Glucagon-like peptide 1 receptor (GLP1R) is a 463-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P43220.
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The mean pLDDT of this model is 81.5 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 47% |
| 70 to 90 | Confident: backbone generally right | 36% |
| 50 to 70 | Low: treat with caution | 6% |
| Below 50 | Very low: often disordered regions | 11% |
What pLDDT means and how to read it
G protein-coupled receptor for glucagon-like peptide 1 (GLP-1) (PubMed:19861722, PubMed:26308095, PubMed:27196125, PubMed:28514449, PubMed:7517895, PubMed:8216285, PubMed:8405712). Ligand binding triggers activation of a signaling cascade that leads to the activation of adenylyl cyclase and increased intracellular cAMP levels (PubMed:19861722, PubMed:26308095, PubMed:27196125, PubMed:28514449, PubMed:7517895, PubMed:8216285, PubMed:8405712). Plays a role in regulating insulin secretion in response to GLP-1 (By similarity)
May form homodimers and heterodimers with GIPR
Cell membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4ZGM | X-ray | 1.8 Å | A=24-145 |
| 5OTU | X-ray | 1.8 Å | A/C=24-139 |
| 5OTT | X-ray | 1.92 Å | A=24-139 |
| 5E94 | X-ray | 2.0 Å | G/H=24-145 |
| 5OTV | X-ray | 2.0 Å | A/C=24-139 |
| 5OTX | X-ray | 2.0 Å | A/C=24-139 |
| 3C5T | X-ray | 2.1 Å | A=24-145 |
| 3IOL | X-ray | 2.1 Å | A=24-145 |
| 5OTW | X-ray | 2.1 Å | A/C=24-139 |
| 6X18 | EM | 2.1 Å | R=24-463 |
| 6X19 | EM | 2.1 Å | R=24-463 |
| 7RTB | EM | 2.14 Å | R=22-463 |
| 9MZE | EM | 2.2 Å | R=24-463 |
| 9N05 | EM | 2.2 Å | R=24-463 |
| 3C59 | X-ray | 2.3 Å | A=24-145 |
| 9BYO | EM | 2.31 Å | R=24-463 |
| 7S1M | EM | 2.41 Å | R=24-463 |
| 8JIS | EM | 2.46 Å | R=30-423 |
| 6X1A | EM | 2.5 Å | R=24-463 |
| 7DUQ | EM | 2.5 Å | R=24-463 |
Showing 20 of 70 experimental structures (best resolution first).
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