Melanoma-associated antigen 4 (MAGEA4) is a 317-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P43358.
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The mean pLDDT of this model is 76.5 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 56% |
| 70 to 90 | Confident: backbone generally right | 10% |
| 50 to 70 | Low: treat with caution | 5% |
| Below 50 | Very low: often disordered regions | 30% |
What pLDDT means and how to read it
Regulates cell proliferation through the inhibition of cell cycle arrest at the G1 phase (PubMed:22842486). Also negatively regulates p53-mediated apoptosis (PubMed:22842486)
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6TRN | X-ray | 1.35 Å | C=230-239 |
| 1I4F | X-ray | 1.4 Å | C=230-239 |
| 2WA0 | X-ray | 2.3 Å | A=99-317 |
| 9BD3 | X-ray | 2.58 Å | A/C=101-317 |
| 8ES8 | EM | 2.65 Å | P=230-239 |
| 6TRO | X-ray | 3.0 Å | C=230-239 |
| 8FJA | EM | 3.0 Å | C=230-239 |
| 8ES9 | EM | 3.25 Å | P=230-239 |
| 7UOA | X-ray | 3.5 Å | A=101-317 |
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