Proteasome activator BLM10 (BLM10) is a 2143-residue protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c). This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P43583.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 81.6 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 42% |
| 70 to 90 | Confident: backbone generally right | 44% |
| 50 to 70 | Low: treat with caution | 3% |
| Below 50 | Very low: often disordered regions | 11% |
What pLDDT means and how to read it
Associated component of the proteasome that specifically recognizes acetylated histones and promotes ATP- and ubiquitin-independent degradation of core histones during DNA damage response. Recognizes and binds acetylated histones via its bromodomain-like (BRDL) region and activates the proteasome by opening the gated channel for substrate entry. Binds to the core proteasome via its C-terminus, which occupies the same binding sites as the proteasomal ATPases, opening the closed structure of the proteasome via an active gating mechanism. Involved in DNA damage response in somatic cells: binds to acetylated histones and promotes degradation of histones following DNA double-strand breaks
According to PubMed:12973301, colocalizes with nascent proteasome. According to PubMed:15778719, associates with proteasome core particles and also forms a complex with regulatory particle-core particle (RP-CP)
Nucleus, Cytoplasm
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 9GBK | EM | 2.39 Å | 3=1-2143 |
| 9D4C | EM | 2.75 Å | O=1-2143 |
| 9D0T | EM | 2.84 Å | O=1-2143 |
| 4V7O | X-ray | 3.0 Å | A5/A7/B4/B7=239-1037, A6/A8/B5/B8=1147-2143, AE/AF/B3/B6=79-154 |
MolViewer loads the AlphaFold model straight from AlphaFold DB into your browser. Show it as a cartoon, color by pLDDT, measure distances and angles, and load a PDB structure next to it to compare.