G-prodeshotein coupled receptor 4 (GPR4) is a 362-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P46093.
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The mean pLDDT of this model is 80.7 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 51% |
| 70 to 90 | Confident: backbone generally right | 26% |
| 50 to 70 | Low: treat with caution | 7% |
| Below 50 | Very low: often disordered regions | 16% |
What pLDDT means and how to read it
Proton-sensing G protein-coupled receptor activated by extracellular pH, which is required to monitor pH changes and generate adaptive reactions (PubMed:12955148, PubMed:17462861, PubMed:33478938, PubMed:39753132, PubMed:39799123, PubMed:40211064, PubMed:40215959, PubMed:40215960). Activated by an optimal pH of 6.8-7.2 (PubMed:12955148, PubMed:17462861, PubMed:39753132). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (PubMed:39753132, PubMed:40211064, PubMed:40215960). GPR4 is mainly coupled to G(s) G proteins and mediates activation of…
Cell membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 9JCO | EM | 2.36 Å | R=1-362 |
| 8Z9O | EM | 2.4 Å | R=8-310 |
| 8Z9P | EM | 2.5 Å | R=8-310 |
| 9JCP | EM | 2.55 Å | R=1-362 |
| 9JCQ | EM | 2.59 Å | D=1-362 |
| 9LMP | EM | 2.65 Å | R=1-221, R=223-362 |
| 9JFV | EM | 2.67 Å | R=1-354 |
| 9IV6 | EM | 2.71 Å | R=1-362 |
| 8Z3Q | EM | 2.76 Å | R=1-362 |
| 9BIP | EM | 2.8 Å | R=1-362 |
| 9LGM | EM | 2.84 Å | R=1-354 |
| 9JFX | EM | 2.87 Å | R=1-354 |
| 8Z3M | EM | 2.9 Å | R=1-362 |
| 8ZCF | EM | 2.9 Å | R=1-323 |
| 9JFZ | EM | 2.9 Å | R=1-354 |
| 8Z65 | EM | 2.97 Å | R=1-362 |
| 8Z66 | EM | 3.06 Å | R=1-362 |
| 8ZCE | EM | 3.1 Å | R=1-354 |
| 9JFW | EM | 3.13 Å | R=1-354 |
| 8Z3Y | EM | 3.2 Å | R=1-362 |
Showing 20 of 25 experimental structures (best resolution first).
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