Protein STU2 (STU2) is a 888-residue protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c). This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P46675.
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The mean pLDDT of this model is 71.8 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 32% |
| 70 to 90 | Confident: backbone generally right | 34% |
| 50 to 70 | Low: treat with caution | 10% |
| Below 50 | Very low: often disordered regions | 25% |
What pLDDT means and how to read it
Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. May play a role in the attachment, organization, and/or dynamics of microtubule ends at the spindle pole body. Stabilizes both cytoplasmic and nuclear microtubules. Promotes mitotic spindle elongation in anaphase. Has microtubule polymerase activity by accelerating microtubule growth and inhibiting catastrophe. The polymerase activity is proposed to involve a tethering mechanism at the microtubule plus end: a curved, longitudinally microtubule lattice-associated tubulin heterodimer (that cannot be incorporated into the microtubule lattice) is bound via one TOG domain while the other TOG…
Binds to microtubules. Homodimer; each monomer can bind via its TOG domains to two alpha/beta-tubulin heterodimers. Interacts with SPC72. Associates with the NDC80 complex
Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body, Cytoplasm, cytoskeleton, spindle, Chromosome, centromere, kinetochore
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 2QK1 | X-ray | 1.7 Å | A=317-560 |
| 6BL7 | X-ray | 2.5 Å | A/B=655-760 |
| 7KDF | X-ray | 2.72 Å | E=856-888 |
| 4U3J | X-ray | 2.81 Å | C=318-560 |
| 4FFB | X-ray | 2.88 Å | C=1-272 |
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