Leptin receptor (LEPR) is a 1165-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P48357.
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The mean pLDDT of this model is 66.0 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 21% |
| 70 to 90 | Confident: backbone generally right | 37% |
| 50 to 70 | Low: treat with caution | 10% |
| Below 50 | Very low: often disordered regions | 33% |
What pLDDT means and how to read it
Receptor for hormone LEP/leptin (Probable) (PubMed:22405007). On ligand binding, mediates LEP central and peripheral effects through the activation of different signaling pathways such as JAK2/STAT3 and MAPK cascade/FOS. In the hypothalamus, LEP acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones (By similarity) (PubMed:9537324). In the periphery, increases basal metabolism, influences reproductive function, regulates pancreatic beta-cell function and insulin secretion, is…
Present as a mixture of monomers and dimers (Probable). The phosphorylated receptor binds a number of SH2 domain-containing proteins such as JAK2, STAT3, PTPN11, and SOCS3 (By similarity) (PubMed:9600917). Interaction with SOCS3 inhibits JAK/STAT signaling and MAPK cascade (By similarity)
Cell membrane, Basolateral cell membrane, Secreted
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3V6O | X-ray | 1.95 Å | A/B=428-633 |
| 6E2P | X-ray | 2.83 Å | C/D=863-933 |
| 8X85 | EM | 3.58 Å | A/B=21-839 |
| 7Z3Q | X-ray | 3.62 Å | B/D/F=428-635 |
| 8X81 | EM | 3.77 Å | A/B/C=21-839 |
| 8X80 | EM | 3.88 Å | A/B/C=21-839 |
| 8AVE | EM | 5.62 Å | B/D=22-839 |
| 8AVF | EM | 6.45 Å | B/D/F=22-839 |
| 8AVO | EM | 6.84 Å | B/D/F=22-839 |
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