P48589: Small ribosomal subunit protein eS12 (RPS12)

Small ribosomal subunit protein eS12 (RPS12) is a 143-residue protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c). This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P48589.

Gene: RPS12
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Length: 143 residues
Mean pLDDT: 82.3
Model: AF-P48589-F1 v6
Model created: 1 Aug 2025
PDB structures: 135

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Model confidence (pLDDT)

The mean pLDDT of this model is 82.3 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.

pLDDT band	Meaning	Share of residues
Above 90	Very high: backbone and side chains are usually accurate	57%
70 to 90	Confident: backbone generally right	27%
50 to 70	Low: treat with caution	3%
Below 50	Very low: often disordered regions	13%

What pLDDT means and how to read it

Function

Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion…

Subunit structure

Component of the small ribosomal subunit (SSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:22096102, PubMed:9559554)

Subcellular location

Cytoplasm

Experimental structures in the PDB

Compare the prediction with experimentally determined structures of the same protein:

PDB ID	Method	Resolution	Chains and residues
8T2Y	EM	2.2 Å	BM=1-143
8ZHC	EM	2.3 Å	SD=20-143
7ZW0	EM	2.4 Å	sD=1-143
8T2Z	EM	2.4 Å	BM=1-143
8T2X	EM	2.46 Å	BM=1-143
7ZUX	EM	2.5 Å	DM=23-143
6T4Q	EM	2.6 Å	SM=23-143
8ZHB	EM	2.6 Å	SD=20-143
9N74	EM	2.65 Å	OH=1-143
7MPJ	EM	2.7 Å	BM=23-143
8ZGR	EM	2.7 Å	SD=20-143
8ZH3	EM	2.7 Å	SD=20-143
4U4R	X-ray	2.8 Å	C2/c2=2-143
6SNT	EM	2.8 Å	M=1-143
6TB3	EM	2.8 Å	D=23-143
8ZGY	EM	2.8 Å	SD=20-143
8T3A	EM	2.86 Å	BM=1-143
8T30	EM	2.88 Å	BM=1-143
4U3U	X-ray	2.9 Å	C2/c2=2-143
6WOO	EM	2.9 Å	MM=20-143

Showing 20 of 135 experimental structures (best resolution first).

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