Casein kinase I isoform alpha (CSNK1A1) is a 337-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P48729.
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The mean pLDDT of this model is 91.4 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 84% |
| 70 to 90 | Confident: backbone generally right | 6% |
| 50 to 70 | Low: treat with caution | 2% |
| Below 50 | Very low: often disordered regions | 8% |
What pLDDT means and how to read it
Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates (PubMed:11955436, PubMed:1409656, PubMed:18305108, PubMed:23902688). Phosphorylates a large number of proteins (PubMed:11955436, PubMed:1409656, PubMed:18305108, PubMed:23902688). Participates in Wnt signaling (PubMed:11955436). Phosphorylates CTNNB1 at 'Ser-45' (PubMed:11955436). May phosphorylate PER1 and PER2 (By similarity). May play a role in segregating chromosomes during mitosis (PubMed:1409656). May play a role in keratin cytoskeleton disassembly and thereby, it may regulate epithelial cell migration (PubMed:23902688). Acts as a positive regulator of mTORC1…
Interacts with the Axin complex (PubMed:11955436). Interacts with TUT1, leading to TUT1 phosphorylation (PubMed:1409656). Interacts with SACK1A, SACK1B, SACK1C, SACK1D, SACK1E, SACK1F, SACK1G and SACK1H (via SACK1 domain) (PubMed:29789297, PubMed:31338967). The interaction with SACK1H recruits CSNK1A1 to keratin filaments (PubMed:23902688). Interacts with FAM170A (By similarity). Interacts with…
Cytoplasm, Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, Chromosome, centromere, kinetochore, Nucleus speckle, Cytoplasm, cytoskeleton, cilium basal body, Cytoplasm, cytoskeleton, spindle
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6GZD | X-ray | 2.28 Å | A=1-337 |
| 5FQD | X-ray | 2.45 Å | C/F=1-337 |
| 9OTY | EM | 3.0 Å | C=10-303 |
| 7WTT | EM | 3.1 Å | a=1-337 |
| 8G66 | X-ray | 3.45 Å | C/F=1-337 |
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