Casein kinase I isoform delta (CSNK1D) is a 415-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P48730.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 81.0 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 66% |
| 70 to 90 | Confident: backbone generally right | 8% |
| 50 to 70 | Low: treat with caution | 4% |
| Below 50 | Very low: often disordered regions | 22% |
What pLDDT means and how to read it
Essential serine/threonine-protein kinase that regulates diverse cellular growth and survival processes including Wnt signaling, DNA repair and circadian rhythms. It can phosphorylate a large number of proteins. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Phosphorylates connexin-43/GJA1, MAP1A, SNAPIN, MAPT/TAU, TOP2A, DCK, HIF1A, EIF6, p53/TP53, DVL2, DVL3, ESR1, AIB1/NCOA3, DNMT1, PKD2, YAP1, PER1 and PER2. Central component of the circadian clock. In balance with PP1, determines the circadian period length through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. Controls PER1…
Monomer (PubMed:22168824, PubMed:23106386). Component of the circadian core oscillator, which includes the CRY proteins, CLOCK, or NPAS2, ARTNL/BMAL1 or ARTNL2/BMAL2, CSNK1D and/or CSNK1E, TIMELESS and the PER proteins (By similarity). Interacts with DNMT1 and MAP1A (By similarity). Interacts directly with PER1 and PER2 which may lead to their degradation (PubMed:11165242). Interacts with…
Cytoplasm, Nucleus, Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, Cytoplasm, perinuclear region, Cell membrane, Cytoplasm, cytoskeleton, spindle, Golgi apparatus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6RCG | X-ray | 1.4 Å | A=1-294 |
| 6RCH | X-ray | 1.45 Å | A/B=1-294 |
| 8IZC | X-ray | 1.45 Å | A/B=5-294 |
| 6PXN | X-ray | 1.55 Å | A/B=1-415 |
| 6GZM | X-ray | 1.59 Å | A/B=1-295 |
| 8D7O | X-ray | 1.65 Å | A/B=1-294 |
| 8D7N | X-ray | 1.66 Å | A/B=1-294 |
| 4TWC | X-ray | 1.7 Å | A/B=1-295 |
| 7P7G | X-ray | 1.7 Å | A/B=1-294 |
| 6HMR | X-ray | 1.78 Å | A/B=1-294 |
| 4HGT | X-ray | 1.8 Å | A/B=1-294 |
| 6F26 | X-ray | 1.83 Å | A/B=1-294 |
| 7NZY | X-ray | 1.85 Å | A/B/C/D=1-294 |
| 6F1W | X-ray | 1.86 Å | A/B=1-294 |
| 5IH4 | X-ray | 1.9 Å | A=1-294 |
| 6RU8 | X-ray | 1.92 Å | A/B/C/D=1-294 |
| 3UZP | X-ray | 1.94 Å | A/B=1-294 |
| 4KB8 | X-ray | 1.95 Å | A/B/C/D=3-317 |
| 7P7F | X-ray | 1.96 Å | A/B/C/D=1-294 |
| 4KBA | X-ray | 1.98 Å | A/B/C/D=3-317 |
Showing 20 of 46 experimental structures (best resolution first).
MolViewer loads the AlphaFold model straight from AlphaFold DB into your browser. Show it as a cartoon, color by pLDDT, measure distances and angles, and load a PDB structure next to it to compare.