Mannan-binding lectin serine protease 1 (MASP1) is a 699-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P48740.
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The mean pLDDT of this model is 90.4 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 79% |
| 70 to 90 | Confident: backbone generally right | 14% |
| 50 to 70 | Low: treat with caution | 4% |
| Below 50 | Very low: often disordered regions | 3% |
What pLDDT means and how to read it
Precursor of a serum protease that activates the complement pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system
Homodimer (PubMed:11290788, PubMed:18596036). Interacts with the oligomeric lectins MBL2, FCN2 and FCN3; triggers the lectin pathway of complement (PubMed:10679061, PubMed:10878362, PubMed:11907111, PubMed:12421953, PubMed:9087411). Interacts with COLEC11; probably triggers the lectin pathway of complement (PubMed:20956340). Interacts with SERPING1 (PubMed:10946292)
Secreted, Cell surface
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3DEM | X-ray | 2.3 Å | A/B=20-297 |
| 7ARX | X-ray | 2.42 Å | A=298-448, B=449-699 |
| 4IGD | X-ray | 2.5 Å | A=298-699 |
| 3GOV | X-ray | 2.55 Å | A=298-448, B=449-699 |
| 4KKD | X-ray | 2.6 Å | A/B=298-696 |
| 4DJZ | X-ray | 3.2 Å | A/C=298-448, B/D=449-699 |
| 4IW4 | X-ray | 3.2 Å | E/F=625-696 |
| 7PQO | X-ray | 3.39 Å | A/B/C=298-699 |
| 4AQB | X-ray | 4.2 Å | A=20-379 |
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