Adhesion G protein-coupled receptor E5 (ADGRE5) is a 835-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P48960.
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The mean pLDDT of this model is 78.1 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 18% |
| 70 to 90 | Confident: backbone generally right | 62% |
| 50 to 70 | Low: treat with caution | 12% |
| Below 50 | Very low: often disordered regions | 8% |
What pLDDT means and how to read it
Receptor potentially involved in both adhesion and signaling processes early after leukocyte activation. Plays an essential role in leukocyte migration
Forms a heterodimer, consisting of a large extracellular region (alpha subunit) non-covalently linked to a seven-transmembrane moiety (beta subunit). Interacts with complement decay-accelerating factor (DAF). The largest isoform (isoform 1) interacts with chondroitin sulfate
Cell membrane, Secreted, extracellular space
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 2BOU | X-ray | 1.9 Å | A=22-32 |
| 8IKL | EM | 2.33 Å | R=531-808 |
| 7YDM | EM | 2.89 Å | R=531-835 |
| 7YDJ | EM | 3.03 Å | R=531-835 |
| 7YDH | EM | 3.1 Å | R=531-835 |
| 7YDP | EM | 3.1 Å | R=531-835 |
| 9MQR | EM | 3.16 Å | A=21-552 |
| 7DO4 | X-ray | 3.2 Å | A=21-258 |
| 8IKJ | EM | 3.2 Å | R=257-720, R=734-808 |
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