Amphiphysin (AMPH) is a 695-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P49418.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 63.1 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 37% |
| 70 to 90 | Confident: backbone generally right | 8% |
| 50 to 70 | Low: treat with caution | 3% |
| Below 50 | Very low: often disordered regions | 52% |
What pLDDT means and how to read it
May participate in mechanisms of regulated exocytosis in synapses and certain endocrine cell types. May control the properties of the membrane associated cytoskeleton
Heterodimer with BIN1 (By similarity). Binds SH3GLB1 (By similarity). Interacts with REPS1 and SGIP1 (PubMed:20946875). Binds AP2A2 (PubMed:12057195). Interacts with AP2B1 (PubMed:16903783). Interacts with DNM1 and SYNJ1 (By similarity)
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane, Cytoplasm, cytoskeleton
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4ATM | X-ray | 1.78 Å | A=1-242 |
| 5M61 | X-ray | 1.84 Å | E/F/G/H=349-360 |
| 5M5S | X-ray | 1.88 Å | E/F/G/H=349-358 |
| 1KY7 | X-ray | 2.15 Å | P=322-331 |
| 1UTC | X-ray | 2.3 Å | P/Q=379-387 |
| 3SOG | X-ray | 2.3 Å | A=34-236 |
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