Nuclear pore complex protein Nup153 (Nup153) is a 1468-residue protein from Rattus norvegicus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P49791.
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The mean pLDDT of this model is 43.6 (very low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 7% |
| 70 to 90 | Confident: backbone generally right | 4% |
| 50 to 70 | Low: treat with caution | 5% |
| Below 50 | Very low: often disordered regions | 85% |
What pLDDT means and how to read it
Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC (By similarity). The repeat-containing domain may be involved in anchoring other components of the NPC to the pore membrane. Possible…
Part of the nuclear pore complex (NPC) (By similarity). Interacts with TPR (via coiled coil region); the interaction is direct and provides a link between the core structure and the TPR-containing nuclear basket of the nuclear pore complex (NPC) (By similarity). Interacts with HIKESHI (By similarity). Interacts with SENP2. Interacts with XPO5 (By similarity). Interacts with RAN; the interaction…
Nucleus, Nucleus membrane, Nucleus, nuclear pore complex
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7MO5 | X-ray | 1.55 Å | B=838-874 |
| 7MO1 | X-ray | 1.6 Å | B=648-687 |
| 7MO2 | X-ray | 1.65 Å | B/D=713-749 |
| 3GJ3 | X-ray | 1.79 Å | B=723-750 |
| 3GJ5 | X-ray | 1.79 Å | B/D=848-876 |
| 3GJ8 | X-ray | 1.82 Å | B/D=790-876 |
| 3GJ7 | X-ray | 1.93 Å | B/D=658-750 |
| 7MO3 | X-ray | 2.05 Å | B/D=781-817 |
| 3CH5 | X-ray | 2.1 Å | B=703-754 |
| 3GJ4 | X-ray | 2.15 Å | B/D=790-817 |
| 7MO4 | X-ray | 2.4 Å | B/D=781-817 |
| 3GJ6 | X-ray | 2.7 Å | B=658-686 |
| 2K0C | NMR | A=703-755 |
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