7MO5: ZnF4 of Nucleoporin NUP153

Crystal Structure of the ZnF4 of Nucleoporin NUP153 in complex with Ran-GDP. Determined by X-ray diffraction at 1.55 Å resolution. Released 15 Jun 2022.

Method: X-ray diffraction
Resolution: 1.55 Å
Organisms: Homo sapiens, Rattus norvegicus
Chains: 2
Atoms: 2,176
Mol. weight: 29.48 kDa
Ligands: GDP, ZN, MG
Released: 15 Jun 2022

Explore 7MO5 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

7MO5 contains 16 α-helices and 16 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 13 helices, 12 β-strands

Element	Residues	Length	Sheet
β-strand	10-17	8	1
α-helix	23-27	5
β-strand	30	1	2
α-helix	31-35	5
β-strand	38-40	3	1
β-strand	45-54	10	1
β-strand	57-66	10	1
α-helix	69-71	3
α-helix	74-76	3
α-helix	77-80	4
β-strand	85-91	7	1
α-helix	95-99	5
α-helix	101-112	12
β-strand	117-122	6	1
α-helix	133-135	3
β-strand	145-148	4	1
β-strand	150	1	3
α-helix	151-153	3
β-strand	155	1	3
α-helix	159-169	11
β-strand	176-178	3	1
α-helix	179-181	3
β-strand	182	1	2
α-helix	183-185	3
α-helix	191-206	16

Chain B: 3 helices, 4 β-strands

Element	Residues	Length	Sheet
α-helix	845-846	2
β-strand	850-851	2	4
β-strand	858-859	2	4
β-strand	865	1	5
α-helix	871	1
β-strand	872	1	5
α-helix	873	1

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
GTP-binding nuclear protein Ran	A	protein	217	Homo sapiens	P62826 (AlphaFold model)
Nuclear pore complex protein Nup153	B	protein	42	Rattus norvegicus	P49791 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>7MO5_1 GTP-binding nuclear protein Ran (chains A)
SMAAQGEPQVQFKLVLVGDGGTGKTTFVKRHLTGESEKKYVATLGVEVHPLVFHTNRGPI
KFNVWDTAGQEKFGGLRDGYYIQAQCAIIMFDVTSRVTYKNVPNWHRDLVRVCENIPIVL
CGNKVDIKDRKVKAKSIVFHRKKNLQYYDISAKSNYNFEKPFLWLARKLIGDPNLEFVAM
PALAPPEVVMDPALAAQYEHDLEVAQTTALPDEDDDL

Sequence of entity 2 (B), FASTA

>7MO5_2 Nuclear pore complex protein Nup153 (chains B)
GPLGSLGLDKFKKPEGSWDCEVCLVQNKADSTKCIACESAKP

Ligands and cofactors

ID	Name	Formula	Copies
GDP	Guanosine-5'-diphosphate	C10 H15 N5 O11 P2	1
ZN	Zinc ion	Zn	1
MG	Magnesium ion	Mg	1

Primary citation

Architecture of the cytoplasmic face of the nuclear pore. Bley, C.J., Nie, S., Mobbs, G.W. et al. Science (2022) 376:eabm9129-eabm9129. DOI 10.1126/science.abm9129 · PubMed

Other PDB entries of the same protein (UniProt P62826 (AlphaFold model), which also has an AlphaFold model), best resolution first:

3GJ0 1.48 Å, Crystal structure of human RanGDP
7MO1 1.6 Å, Crystal Structure of the ZnF1 of Nucleoporin NUP153 in complex with Ran-GDP
5CIQ 1.65 Å, Ran GDP wild type tetragonal crystal form
7MO2 1.65 Å, Crystal Structure of the ZnF2 of Nucleoporin NUP153 in complex with Ran-GDP
5CIT 1.75 Å, Ran GDP wild type monoclinic crystal form
5CIW 1.75 Å, Ran GDP Y39A mutant monoclinic crystal form
5CJ2 1.75 Å, Ran GDP Y39A mutant triclinic crystal form
1I2M 1.76 Å, Ran-RCC1-SO4 complex
4HAT 1.78 Å, Crystal structure of CRM1 inhibitor Leptomycin B in complex with CRM1-Ran-RanBP1
3GJ3 1.79 Å, Crystal structure of human RanGDP-Nup153ZnF2 complex
3GJ5 1.79 Å, Crystal structure of human RanGDP-Nup153ZnF4 complex
4HB2 1.8 Å, Crystal structure of CRM1-Ran-RanBP1

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