Tumor necrosis factor ligand superfamily member 10 (TNFSF10) is a 281-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P50591.
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The mean pLDDT of this model is 81.7 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 52% |
| 70 to 90 | Confident: backbone generally right | 20% |
| 50 to 70 | Low: treat with caution | 18% |
| Below 50 | Very low: often disordered regions | 10% |
What pLDDT means and how to read it
Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG (PubMed:10549288, PubMed:26457518). Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis
Homotrimer (PubMed:26457518). One TNFSF10 homotrimer interacts with three TNFSF10A monomers (PubMed:26457518). One TNFSF10 homotrimer interacts with three TNFSF10B monomers (PubMed:10549288)
Cell membrane, Secreted
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 1DG6 | X-ray | 1.3 Å | A=91-281 |
| 1D4V | X-ray | 2.2 Å | B=119-281 |
| 1DU3 | X-ray | 2.2 Å | D/E/F/J/K/L=114-281 |
| 1D0G | X-ray | 2.4 Å | A/B/D=114-281 |
| 1D2Q | X-ray | 2.8 Å | A/B=114-281 |
| 5CIR | X-ray | 3.0 Å | A/B/D=113-281 |
| 4N90 | X-ray | 3.3 Å | A/B/C=114-281 |
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