P2X purinoceptor 4 (P2rx4) is a 388-residue protein from Rattus norvegicus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P51577.
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The mean pLDDT of this model is 89.3 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 66% |
| 70 to 90 | Confident: backbone generally right | 27% |
| 50 to 70 | Low: treat with caution | 5% |
| Below 50 | Very low: often disordered regions | 1% |
What pLDDT means and how to read it
ATP-gated nonselective transmembrane cation channel permeable to potassium, sodium and calcium. CTP, but not GTP or UTP, functions as a weak affinity agonist for P2RX4 (PubMed:28332633, PubMed:8622997). Activated by extracellularly released ATP, it plays multiple role in immunity and central nervous system physiology (PubMed:15985462, PubMed:24762105). Plays a key role in initial steps of T-cell activation and Ca(2+) microdomain formation (By similarity). Also participates in basal T-cell activity without TCR/CD3 stimulation (By similarity). Promotes the differentiation and activation of Th17 cells via expression of retinoic acid-related orphan receptor C/RORC (By similarity). Upon…
Functional P2RXs are organized as homomeric and heteromeric trimers. Forms heterotrimer with P2RX1 (PubMed:15686495). Interacts with P2RX7 (via C-terminus); this interaction is functional only in the presence of ATP (By similarity). Forms heterotrimer with P2RX4; functional differences between homomeric P2RX4 and P2RX4/6 heterotrimer are minor (PubMed:12077178). Interacts with AP1M2…
Cell membrane, Lysosome membrane
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