Ubiquitin-conjugating enzyme E2 D1 (UBE2D1) is a 147-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P51668.
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The mean pLDDT of this model is 96.4 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 97% |
| 70 to 90 | Confident: backbone generally right | 3% |
| 50 to 70 | Low: treat with caution | 0% |
| Below 50 | Very low: often disordered regions | 0% |
What pLDDT means and how to read it
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins (PubMed:22496338). In vitro catalyzes 'Lys-48'-linked polyubiquitination (PubMed:20061386). Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and auto-ubiquitination of STUB1, TRAF6 and TRIM63/MURF1 (PubMed:18042044, PubMed:18359941). Ubiquitinates STUB1-associated HSP90AB1 in vitro (PubMed:18042044). Lacks inherent specificity for any particular lysine residue of ubiquitin (PubMed:18042044). Essential for viral activation of IRF3 (PubMed:19854139). Mediates polyubiquitination of…
Component of a E3 ubiquitin ligase complex containing UBE2D1, SIAH1, CACYBP/SIP, SKP1, APC and TBL1X. Interacts with RNF11
Cytoplasm
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4QPL | X-ray | 1.9 Å | B/D=1-147 |
| 2YHO | X-ray | 2.1 Å | B/D/F/H=1-147 |
| 6D4P | X-ray | 2.11 Å | A=1-147 |
| 4AP4 | X-ray | 2.21 Å | B/E=1-147 |
| 5FER | X-ray | 2.34 Å | B/E=1-147 |
| 2C4P | X-ray | 2.35 Å | A/B=1-147 |
| 7ZJ3 | X-ray | 2.53 Å | B/E/H/K=2-146 |
| 5TUT | X-ray | 2.6 Å | A=1-147 |
| 3PTF | X-ray | 2.7 Å | A/B=1-147 |
| 3OJ4 | X-ray | 3.4 Å | A/D=1-147 |
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