Ubiquitin-conjugating enzyme E2 E1 (UBE2E1) is a 193-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P51965.
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The mean pLDDT of this model is 86.7 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 77% |
| 70 to 90 | Confident: backbone generally right | 1% |
| 50 to 70 | Low: treat with caution | 10% |
| Below 50 | Very low: often disordered regions | 12% |
What pLDDT means and how to read it
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes the covalent attachment of ISG15 to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. In vitro also catalyzes 'Lys-48'-linked polyubiquitination. Catalyzes monoubiquitination of other proteins in both an E3-dependent and E3-independent manner (PubMed:27237050)
Interacts with RNF14
Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 5LBN | X-ray | 1.42 Å | A=37-193 |
| 3BZH | X-ray | 1.6 Å | A=1-193 |
| 1XR9 | X-ray | 1.79 Å | C=83-91 |
| 4JJQ | X-ray | 1.95 Å | B=5-14 |
| 8IYA | X-ray | 2.43 Å | A/B/C=41-193 |
| 6FGA | X-ray | 2.82 Å | I/J/K/L/M/N/O=37-193 |
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