Suppressor of kinetochore protein 1 (SKP1) is a 194-residue protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c). This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P52286.
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The mean pLDDT of this model is 83.1 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 58% |
| 70 to 90 | Confident: backbone generally right | 18% |
| 50 to 70 | Low: treat with caution | 13% |
| Below 50 | Very low: often disordered regions | 11% |
What pLDDT means and how to read it
Essential component of the E3 ubiquitin ligase complex SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins like phosphorylated SIC1. Participates in the attachment of chromosomes to the spindle. Acts as a regulatory component of the centromere DNA-binding protein complex CBF3, which is essential for chromosome segregation and movement of centromeres along microtubules. CBF3 is required for the recruitment of other kinetochore complexes to CEN DNA. It plays a role in the attachment of chromosomes to the spindle and binds selectively to a highly conserved DNA sequence called CDEIII, found in…
Component of the E3 ubiquitin ligase complexes SCF with HRT1, some cullins like CDC53, and some F-box proteins like MET30 CDC4 and SAF1. Interacts with CDC53 and MET30 to form the E3 ubiquitin ligase complex SCF(Met30) which also contains MET4. Forms complex SCF(Cdc4) together with CDC4 and CDC53. Component of the CBF3 complex, which is formed of CBF3A/CBF2, CBF3B/CEP3, CBF3C/CTF13 and CBF3D.…
Cytoplasm, Nucleus, Chromosome, centromere, kinetochore
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 8GRE | X-ray | 2.3 Å | D=1-194 |
| 3V7D | X-ray | 2.31 Å | A/C=1-194 |
| 8GRF | X-ray | 2.53 Å | D=1-194 |
| 3MKS | X-ray | 2.6 Å | A/C=2-194 |
| 1NEX | X-ray | 2.7 Å | A/C=1-194 |
| 9COP | EM | 2.7 Å | z=1-194 |
| 5AN3 | X-ray | 2.82 Å | D=1-35, D=65-158 |
| 6GYU | EM | 3.0 Å | D=1-194 |
| 7PMK | EM | 3.2 Å | K=1-194 |
| 7PMN | EM | 3.2 Å | K=1-194 |
| 6F07 | EM | 3.6 Å | D=1-194 |
| 6GYP | EM | 3.6 Å | D=1-194 |
| 6FE8 | EM | 3.7 Å | C=2-194 |
| 8OW1 | EM | 3.7 Å | SK=1-194 |
| 7K79 | EM | 4.0 Å | N=1-194 |
| 6GSA | EM | 4.2 Å | C=2-194 |
| 6GYS | EM | 4.4 Å | D/K=1-194 |
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