7PMN: S. cerevisiae replisome-SCF(Dia2) complex

S. cerevisiae replisome-SCF(Dia2) complex bound to double-stranded DNA (conformation II). Determined by electron microscopy at 3.2 Å resolution. Released 10 Nov 2021.

Method: Electron microscopy
Resolution: 3.2 Å
Organisms: Saccharomyces cerevisiae, Synthetic construct
Chains: 22
Atoms: 74,640
Mol. weight: 1811.45 kDa
Ligands: ANP, MG, ZN
Released: 10 Nov 2021

Explore 7PMN in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

7PMN contains 484 α-helices and 405 β-strands across 20 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain 2: 35 helices, 30 β-strands

Element	Residues	Length	Sheet
α-helix	183-187	5
α-helix	194-198	5
α-helix	201-217	17
β-strand	219	1	1
β-strand	225	1	1
α-helix	226-236	11
β-strand	241-245	5	2
α-helix	246-251	6
α-helix	254-262	9
α-helix	264-282	19
α-helix	286-288	3
β-strand	294-298	5	2
β-strand	304	1	3
α-helix	306-308	3
α-helix	311-313	3
β-strand	317-327	11	3
β-strand	331-341	11	3
β-strand	347-352	6	3
β-strand	364	1	4
β-strand	369	1	4
β-strand	373-391	19	3
α-helix	398	1
α-helix	402-404	3
β-strand	405-411	7	3
α-helix	412-414	3
β-strand	422-433	12	3
α-helix	436-442	7
β-strand	446	1	5
α-helix	447	1
β-strand	448-458	11	3
α-helix	478-488	11
α-helix	493-500	8
α-helix	509-520	12
β-strand	525-527	3	6
β-strand	531-533	3	6
β-strand	539-543	5	7
α-helix	549-559	11
β-strand	563-567	5	7
α-helix	568-570	3
β-strand	571	1	8
α-helix	573-576	4
β-strand	578-582	5	9
β-strand	589-593	5	9
α-helix	595-598	4
β-strand	603-607	5	7
α-helix	609-611	3
α-helix	614-617	4
α-helix	620-625	6
β-strand	628-633	6	10
β-strand	636-641	6	10
β-strand	645-650	6	7
α-helix	653-655	3
α-helix	663-666	4
α-helix	671-676	6
β-strand	679-683	5	7
β-strand	686	1	11
α-helix	689-705	17
α-helix	740-753	14
α-helix	760-773	14
β-strand	777	1	12
α-helix	783-796	14
α-helix	807-823	17
β-strand	828	1	12
α-helix	831-846	16
α-helix	851-865	15

Chain 3: 35 helices, 27 β-strands

Element	Residues	Length	Sheet
α-helix	17-34	18
α-helix	37-54	18
α-helix	91-93	3
β-strand	95-99	5	13
α-helix	100-106	7
α-helix	108-116	9
α-helix	118-135	18
β-strand	154-158	5	13
α-helix	162-164	3
β-strand	165-166	2	14
α-helix	173-175	3
β-strand	179-187	9	14
α-helix	189-192	4
β-strand	193-203	11	14
β-strand	209-213	5	14
α-helix	230-232	3
β-strand	234	1	15
β-strand	240	1	15
β-strand	241-243	3	14
β-strand	249-259	11	14
α-helix	260-261	2
α-helix	270-272	3
β-strand	273-279	7	14
α-helix	280-282	3
β-strand	291-301	11	14
α-helix	316	1
β-strand	317	1	16
β-strand	318-328	11	14
α-helix	344-354	11
α-helix	359-366	8
α-helix	375-385	11
α-helix	388-390	3
β-strand	391-392	2	17
α-helix	394-396	3
β-strand	398-399	2	17
β-strand	405-409	5	18
α-helix	415-425	11
β-strand	429-432	4	18
β-strand	444-447	4	19
β-strand	456-459	4	19
α-helix	461-464	4
β-strand	469-472	4	18
α-helix	475-477	3
α-helix	480-492	13
β-strand	494-497	4	20
β-strand	504-507	4	20
β-strand	511-516	6	18
α-helix	529-532	4
α-helix	537-540	4
β-strand	545-549	5	18
α-helix	555-569	15
α-helix	576-577	2
α-helix	580-583	4
α-helix	586-589	4
α-helix	650-652	3
α-helix	653-666	14
β-strand	670-671	2	21
α-helix	673-686	14
α-helix	691-694	4
α-helix	699-716	18
β-strand	720-721	2	21
α-helix	723-738	16

Chain 4: 35 helices, 32 β-strands

Element	Residues	Length	Sheet
β-strand	177-180	4	22
β-strand	185-186	2	22
α-helix	187-198	12
β-strand	202	1	23
α-helix	204-209	6
α-helix	213-215	3
α-helix	218-221	4
β-strand	224	1	23
α-helix	225-236	12
β-strand	240-244	5	24
α-helix	245-249	5
α-helix	252-254	3
α-helix	255-263	9
α-helix	265-286	22
α-helix	293-298	6
β-strand	302-306	5	24
α-helix	314-316	3
α-helix	319-321	3
β-strand	325-335	11	25
α-helix	336-338	3
β-strand	339-349	11	25
β-strand	355-359	5	25
β-strand	361	1	26
β-strand	364	1	26
β-strand	370	1	27
β-strand	379	1	27
β-strand	382-384	3	25
α-helix	386-388	3
β-strand	390-400	11	25
α-helix	401-402	2
β-strand	414-420	7	25
α-helix	421-423	3
β-strand	432-442	11	25
β-strand	445	1	28
β-strand	453-454	2	28
β-strand	456	1	29
α-helix	457	1
β-strand	458-468	11	25
α-helix	506-513	8
α-helix	518-525	8
α-helix	534-545	12
β-strand	564-566	3	30
α-helix	574-584	11
β-strand	589-592	4	30
β-strand	603-604	2	31
β-strand	617-618	2	31
α-helix	620-623	4
β-strand	628-632	5	30
α-helix	634-636	3
α-helix	639-651	13
β-strand	653-658	6	32
β-strand	661-666	6	32
β-strand	670-674	5	30
α-helix	688-692	5
α-helix	696-699	4
β-strand	704-706	3	30
α-helix	714-725	12
α-helix	726-728	3
α-helix	744-757	14
α-helix	760	1
β-strand	761-762	2	33
α-helix	763	1
α-helix	764-778	15
α-helix	795-808	14
α-helix	811-813	3
β-strand	816-817	2	33
α-helix	819-833	15

Chain 5: 36 helices, 30 β-strands

Element	Residues	Length	Sheet
α-helix	21-37	17
β-strand	40	1	34
β-strand	43	1	34
α-helix	45-55	11
β-strand	60-64	5	35
α-helix	65-71	7
α-helix	73-81	9
α-helix	83-100	18
α-helix	134-135	2
β-strand	136-140	5	35
α-helix	143-147	5
α-helix	153-155	3
β-strand	159-169	11	16
α-helix	170-172	3
β-strand	173-183	11	16
β-strand	189-193	5	16
β-strand	241-243	3	16
β-strand	249-259	11	16
α-helix	260-261	2
α-helix	262-264	3
α-helix	266	1
α-helix	269-272	4
β-strand	273-279	7	16
α-helix	280-282	3
β-strand	291-301	11	16
β-strand	323	1	3
β-strand	325-334	10	16
α-helix	353-362	10
α-helix	366-373	8
α-helix	382-393	12
β-strand	398-399	2	36
β-strand	405-406	2	36
β-strand	412-416	5	37
α-helix	422-432	11
β-strand	436-440	5	37
α-helix	441-443	3
β-strand	444	1	10
α-helix	446-449	4
β-strand	451-455	5	38
β-strand	462-466	5	38
α-helix	468-471	4
β-strand	475-480	6	37
α-helix	482-484	3
α-helix	487-494	8
α-helix	495-499	5
β-strand	501-506	6	39
β-strand	509-514	6	39
β-strand	517-523	7	37
α-helix	524-525	2
α-helix	536-539	4
α-helix	544-548	5
β-strand	552-556	5	37
α-helix	562-576	15
α-helix	579-589	11
α-helix	596-609	14
β-strand	613-614	2	40
α-helix	616-640	25
α-helix	650-666	17
β-strand	671-672	2	40
α-helix	674-692	19
α-helix	711-721	11
β-strand	727-729	3	41
α-helix	730-738	9
α-helix	747-757	11
β-strand	762-764	3	41
β-strand	769-771	3	41

Chain 6: 35 helices, 36 β-strands

Element	Residues	Length	Sheet
β-strand	94-97	4	42
α-helix	99-101	3
α-helix	106-121	16
α-helix	135-146	12
β-strand	150-154	5	43
α-helix	155-160	6
α-helix	161-164	4
α-helix	165-172	8
α-helix	174-192	19
α-helix	194-197	4
β-strand	198	1	44
α-helix	256-259	4
β-strand	260	1	44
α-helix	261-262	2
β-strand	264-268	5	43
β-strand	274	1	5
α-helix	276-278	3
α-helix	281-283	3
β-strand	284	1	5
β-strand	287-297	11	5
α-helix	298-300	3
β-strand	301-311	11	5
β-strand	317-322	6	5
β-strand	344-346	3	5
β-strand	352-362	11	5
α-helix	373-375	3
β-strand	376-382	7	5
α-helix	383-385	3
β-strand	394-405	12	5
β-strand	412	1	45
β-strand	415	1	45
α-helix	416-418	3
β-strand	437	1	46
β-strand	438	1	26
α-helix	441-443	3
β-strand	448	1	46
β-strand	450-461	12	5
α-helix	501-505	5
α-helix	510-521	12
α-helix	525-532	8
α-helix	541-552	12
β-strand	557-558	2	47
β-strand	564-565	2	47
β-strand	571-575	5	48
α-helix	581-591	11
β-strand	595-599	5	48
β-strand	603	1	32
α-helix	605-608	4
β-strand	610-614	5	49
β-strand	621-625	5	49
α-helix	627-630	4
β-strand	634-639	6	48
α-helix	641-643	3
α-helix	646-649	4
α-helix	653-657	5
β-strand	660-665	6	8
β-strand	668-673	6	8
β-strand	676-682	7	48
α-helix	683-684	2
α-helix	695-698	4
α-helix	703-706	4
β-strand	711-715	5	48
α-helix	721-734	14
α-helix	748-758	11
β-strand	764-765	2	50
α-helix	767-784	18
β-strand	786	1	11
β-strand	791	1	11
α-helix	797-813	17
β-strand	818-819	2	50
α-helix	821-832	12

Chain 7: 34 helices, 28 β-strands

Element	Residues	Length	Sheet
β-strand	7-8	2	14
α-helix	14-27	14
α-helix	31-33	3
α-helix	62-71	10
β-strand	77-81	5	51
α-helix	82-94	13
α-helix	102-108	7
α-helix	110-124	15
α-helix	125-128	4
α-helix	134-136	3
α-helix	138-154	17
α-helix	194-197	4
β-strand	201-205	5	51
α-helix	207-209	3
α-helix	220-222	3
β-strand	224-226	3	29
α-helix	227-229	3
α-helix	232-234	3
β-strand	238-248	11	29
α-helix	249-251	3
β-strand	252-262	11	29
β-strand	269-272	4	29
β-strand	277-278	2	28
β-strand	283	1	52
α-helix	287-290	4
β-strand	297	1	52
β-strand	298-316	19	29
α-helix	326-329	4
β-strand	330-336	7	29
α-helix	337-339	3
β-strand	348-358	11	29
β-strand	371	1	14
α-helix	372	1
β-strand	373-383	11	29
α-helix	397-400	4
α-helix	402-405	4
α-helix	410-416	7
α-helix	426-437	12
β-strand	442	1	53
β-strand	450	1	53
β-strand	456-459	4	54
α-helix	466-476	11
β-strand	480-484	5	54
β-strand	496-499	4	55
β-strand	506-509	4	55
α-helix	512-515	4
β-strand	519-524	6	54
α-helix	526-528	3
α-helix	531-543	13
β-strand	545-550	6	56
β-strand	553-558	6	56
β-strand	561-567	7	54
α-helix	580-582	3
α-helix	588-593	6
β-strand	596-599	4	54
α-helix	606-622	17
α-helix	635-646	12
β-strand	651	1	57
α-helix	654-670	17
α-helix	686-702	17
β-strand	707	1	57
α-helix	710-727	18

Chain A: 9 helices, 6 β-strands

Element	Residues	Length	Sheet
α-helix	4-22	19
α-helix	27-29	3
α-helix	34-57	24
α-helix	67-100	34
α-helix	101-105	5
α-helix	120-122	3
α-helix	125-141	17
β-strand	162-166	5	58
β-strand	167	1	59
β-strand	172-176	5	60
β-strand	179-183	5	60
β-strand	188-192	5	58
α-helix	193-195	3
α-helix	197-201	5
β-strand	205	1	59

Chain B: 12 helices, 4 β-strands

Element	Residues	Length	Sheet
α-helix	5-7	3
α-helix	13-20	8
β-strand	24-29	6	61
α-helix	57-61	5
β-strand	69-72	4	61
α-helix	73-81	9
β-strand	85-87	3	61
α-helix	88-90	3
α-helix	91-93	3
α-helix	95-107	13
α-helix	112-113	2
α-helix	119-129	11
α-helix	138-159	22
α-helix	160-162	3
β-strand	168-169	2	62
α-helix	175-199	25

12 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
DNA replication licensing factor MCM2	2	protein	868	Saccharomyces cerevisiae	P29469 (AlphaFold model)
DNA replication licensing factor MCM3	3	protein	1009	Saccharomyces cerevisiae	P24279 (AlphaFold model)
DNA replication licensing factor MCM4	4	protein	933	Saccharomyces cerevisiae	P30665 (AlphaFold model)
Minichromosome maintenance protein 5	5	protein	775	Saccharomyces cerevisiae	P29496 (AlphaFold model)
DNA replication licensing factor MCM6	6	protein	1017	Saccharomyces cerevisiae	P53091
DNA replication licensing factor MCM7	7	protein	845	Saccharomyces cerevisiae	P38132
DNA replication complex GINS protein PSF1	A	protein	208	Saccharomyces cerevisiae	Q12488
DNA replication complex GINS protein PSF2	B	protein	213	Saccharomyces cerevisiae	P40359
DNA replication complex GINS protein PSF3	C	protein	194	Saccharomyces cerevisiae	A0A6L1BWJ4
DNA replication complex GINS protein SLD5	D	protein	294	Saccharomyces cerevisiae	Q03406
Cell division control protein 45,Cell division control protein 45	E	protein	657	Saccharomyces cerevisiae	Q08032
DNA polymerase alpha-binding protein	F, G, H	protein	962	Saccharomyces cerevisiae	Q01454

8 more molecules are not listed.

Sequence of entity 1 (2), FASTA

>7PMN_1 DNA replication licensing factor MCM2 (chains 2)
MSDNRRRRREEDDSDSENELPPSSPQQHFRGGMNPVSSPIGSPDMINPEGDDNEVDDVPD
IDEVEEQMNEVDLMDDNMYEDYAADHNRDRYDPDQVDDREQQELSLSERRRIDAQLNERD
RLLRNVAYIDDEDEEQEGAAQLDEMGLPVQRRRRRRQYEDLENSDDDLLSDMDIDPLREE
LTLESLSNVKANSYSEWITQPNVSRTIARELKSFLLEYTDETGRSVYGARIRTLGEMNSE
SLEVNYRHLAESKAILALFLAKCPEEMLKIFDLVAMEATELHYPDYARIHSEIHVRISDF
PTIYSLRELRESNLSSLVRVTGVVTRRTGVFPQLKYVKFNCLKCGSILGPFFQDSNEEIR
ISFCTNCKSKGPFRVNGEKTVYRNYQRVTLQEAPGTVPPGRLPRHREVILLADLVDVSKP
GEEVEVTGIYKNNYDGNLNAKNGFPVFATIIEANSIKRREGNTANEGEEGLDVFSWTEEE
EREFRKISRDRGIIDKIISSMAPSIYGHRDIKTAVACSLFGGVPKNVNGKHSIRGDINVL
LLGDPGTAKSQILKYVEKTAHRAVFATGQGASAVGLTASVRKDPITKEWTLEGGALVLAD
KGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKAGIVTTLQARCSIIAAANPNGGRYNST
LPLAQNVSLTEPILSRFDILCVVRDLVDEEADERLATFVVDSHVRSHPENDEDREGEELK
NNGESAIEQGEDEINEQLNARQRRLQRQRKKEEEISPIPQELLMKYIHYARTKIYPKLHQ
MDMDKVSRVYADLRRESISTGSFPITVRHLESILRIAESFAKMRLSEFVSSYDLDRAIKV
VVDSFVDAQKVSVRRQLRRSFAIYTLGH

Sequence of entity 2 (3), FASTA

>7PMN_2 DNA replication licensing factor MCM3 (chains 3)
MKRRWKKNFIAVSAANRFKKISSSGALENLYFQGEAPVMEGSTGFDGDATTFFAPDAVFG
DRVRRFQEFLDTFTSYRDSVRSIQVYNSNNAANYNDDQDDADERDLLGDDDGDDLEKEKK
AASSTSLNILPHRIIISLDDLREFDRSFWSGILVEPAYFIPPAEKALTDLADSMDDVPHP
NASAVSSRHPWKLSFKGSFGAHALSPRTLTAQHLNKLVSVEGIVTKTSLVRPKLIRSVHY
AAKTGRFHYRDYTDATTTLTTRIPTPAIYPTEDTEGNKLTTEYGYSTFIDHQRITVQEMP
EMAPAGQLPRSIDVILDDDLVDKTKPGDRVNVVGVFKSLGAGGMNQSNSNTLIGFKTLIL
GNTVYPLHARSTGVAARQMLTDFDIRNINKLSKKKDIFDILSQSLAPSIYGHDHIKKAIL
LMLMGGVEKNLENGSHLRGDINILMVGDPSTAKSQLLRFVLNTASLAIATTGRGSSGVGL
TAAVTTDRETGERRLEAGAMVLADRGVVCIDEFDKMTDVDRVAIHEVMEQQTVTIAKAGI
HTTLNARCSVIAAANPVFGQYDVNRDPHQNIALPDSLLSRFDLLFVVTDDINEIRDRSIS
EHVLRTHRYLPPGYLEGEPVRERLNLSLAVGEDADINPEEHSNSGAGVENEGEDDEDHVF
EKFNPLLQAGAKLAKNKGNYNGTEIPKLVTIPFLRKYVQYAKERVIPQLTQEAINVIVKN
YTDLRNDDNTKKSPITARTLETLIRLATAHAKVRLSKTVNKVDAKVAANLLRFALLGEDI
GNDIDEEESEYEEALSKRSPQKSPKKRQRVRQPASNSGSPIKSTPRRSTASSVNATPSSA
RRILRFQDDEQNAGEDDNDIMSPLPADEEAELQRRLQLGLRVSPRRREHLHAPEEGSSGP
LTEVGTPRLPNVSSAGQDDEQQQSVISFDNVEPGTISTGRLSLISGIIARLMQTEIFEEE
SYPVASLFERINEELPEEEKFSAQEYLAGLKIMSDRNNLMVADDKVWRV

Sequence of entity 3 (4), FASTA

>7PMN_3 DNA replication licensing factor MCM4 (chains 4)
MSQQSSSPTKEDNNSSSPVVPNPDSVPPQLSSPALFYSSSSSQGDIYGRNNSQNLSQGEG
NIRAAIGSSPLNFPSSSQRQNSDVFQSQGRQGRIRSSASASGRSRYHSDLRSDRALPTSS
SSLGRNGQNRVHMRRNDIHTSDLSSPRRIVDFDTRSGVNTLDTSSSSAPPSEASEPLRII
WGTNVSIQECTTNFRNFLMSFKYKFRKILDEREEFINNTTDEELYYIKQLNEMRELGTSN
LNLDARNLLAYKQTEDLYHQLLNYPQEVISIMDQTIKDCMVSLIVDNNLDYDLDEIETKF
YKVRPYNVGSCKGMRELNPNDIDKLINLKGLVLRSTPVIPDMKVAFFKCNVCDHTMAVEI
DRGVIQEPARCERIDCNEPNSMSLIHNRCSFADKQVIKLQETPDFVPDGQTPHSISLCVY
DELVDSCRAGDRIEVTGTFRSIPIRANSRQRVLKSLYKTYVDVVHVKKVSDKRLDVDTST
IEQELMQNKVDHNEVEEVRQITDQDLAKIREVAAREDLYSLLARSIAPSIYELEDVKKGI
LLQLFGGTNKTFTKGGRYRGDINILLCGDPSTSKSQILQYVHKITPRGVYTSGKGSSAVG
LTAYITRDVDTKQLVLESGALVLSDGGVCCIDEFDKMSDSTRSVLHEVMEQQTISIAKAG
IITTLNARSSILASANPIGSRYNPNLPVTENIDLPPPLLSRFDLVYLVLDKVDEKNDREL
AKHLTNLYLEDKPEHISQDDVLPVEFLTMYISYAKEHIHPIITEAAKTELVRAYVGMRKM
GDDSRSDEKRITATTRQLESMIRLAEAHAKMKLKNVVELEDVQEAVRLIRSAIKDYATDP
KTGKIDMNLVQTGKSVIQRKLQEDLSREIMNVLKDQASDSMSFNELIKQINEHSQDRVES
SDIQEALSRLQQEDKVIVLGEGVRRSVRLNNRV

Sequence of entity 4 (5), FASTA

>7PMN_4 Minichromosome maintenance protein 5 (chains 5)
MSFDRPEIYSAPVLQGESPNDDDNTEIIKSFKNFILEFRLDSQFIYRDQLRNNILVKNYS
LTVNMEHLIGYNEDIYKKLSDEPSDIIPLFETAITQVAKRISILSRAQSANNNDKDPENT
SMDTDSLLLNSLPTFQLILNSNANQIPLRDLDSEHVSKIVRLSGIIISTSVLSSRATYLS
IMCRNCRHTTSITINNFNSITGNTVSLPRSCLSTIESESSMANESNIGDESTKKNCGPDP
YIIIHESSKFIDQQFLKLQEIPELVPVGEMPRNLTMTCDRYLTNKVIPGTRVTIVGIYSI
YNSKNGAGSGRSGGGNGGSGVAIRTPYIKILGIQSDVETSSIWNSVTMFTEEEEEEFLQL
SRNPKLYEILTNSIAPSIFGNEDIKKAIVCLLMGGSKKILPDGMRLRGDINVLLLGDPGT
AKSQLLKFVEKVSPIAVYTSGKGSSAAGLTASVQRDPMTREFYLEGGAMVLADGGVVCID
EFDKMRDEDRVAIHEAMEQQTISIAKAGITTVLNSRTSVLAAANPIYGRYDDLKSPGDNI
DFQTTILSRFDMIFIVKDDHNEERDISIANHVINIHTGNANAMQNQQEENGSEISIEKMK
RYITYCRLKCAPRLSPQAAEKLSSNFVTIRKQLLINELESTERSSIPITIRQLEAIIRIT
ESLAKLELSPIAQERHVDEAIRLFQASTMDAASQDPIGGLNQASGTSLSEIRRFEQELKR
RLPIGWSTSYQTLRREFVDTHRFSQLALDKALYALEKHETIQLRHQGQNIYRSGV

Sequence of entity 5 (6), FASTA

>7PMN_5 DNA replication licensing factor MCM6 (chains 6)
MSSPFPADTPSSNRPSNSSPPPSSIGAGFGSSSGLDSQIGSRLHFPSSSQPHVSNSQTGP
FVNDSTQFSSQRLQTDGSATNDMEGNEPARSFKSRALNHVKKVDDVTGEKVREAFEQFLE
DFSVQSTDTGEVEKVYRAQIEFMKIYDLNTIYIDYQHLSMRENGALAMAISEQYYRFLPF
LQKGLRRVVRKYAPELLNTSDSLKRSEGDEGQADEDEQQDDDMNGSSLPRDSGSSAAPGN
GTSAMATRSITTSTSPEQTERVFQISFFNLPTVHRIRDIRSEKIGSLLSISGTVTRTSEV
RPELYKASFTCDMCRAIVDNVEQSFKYTEPTFCPNPSCENRAFWTLNVTRSRFLDWQKVR
IQENANEIPTGSMPRTLDVILRGDSVERAKPGDRCKFTGVEIVVPDVTQLGLPGVKPSST
LDTRGISKTTEGLNSGVTGLRSLGVRDLTYKISFLACHVISIGSNIGASSPDANSNNRET
ELQMAANLQANNVYQDNERDQEVFLNSLSSDEINELKEMVKDEHIYDKLVRSIAPAVFGH
EAVKKGILLQMLGGVHKSTVEGIKLRGDINICVVGDPSTSKSQFLKYVVGFAPRSVYTSG
KASSAAGLTAAVVRDEEGGDYTIEAGALMLADNGICCIDEFDKMDISDQVAIHEAMEQQT
ISIAKAGIHATLNARTSILAAANPVGGRYNRKLSLRGNLNMTAPIMSRFDLFFVILDDCN
EKIDTELASHIVDLHMKRDEAIEPPFSAEQLRRYIKYARTFKPILTKEARSYLVEKYKEL
RKDDAQGFSRSSYRITVRQLESMIRLSEAIARANCVDEITPSFIAEAYDLLRQSIIRVDV
DDVEMDEEFDNIESQSHAASGNNDDNDDGTGSGVITSEPPADIEEGQSEATARPGTSEKK
KTTVTYDKYVSMMNMIVRKIAEVDREGAEELTAVDIVDWYLLQKENDLGSLAEYWEERRL
AFKVIKRLVKDRILMEIHGTRHNLRDLENEENENNKTVYVIHPNCEVLDQLEPQDSS

Sequence of entity 6 (7), FASTA

>7PMN_6 DNA replication licensing factor MCM7 (chains 7)
MSAALPSIQLPVDYNNLFNEITDFLVTFKQDTLSSDATRNENEDENLDAENIEQHLLEKG
PKYMAMLQKVANRELNSVIIDLDDILQYQNEKFLQGTQADDLVSAIQQNANHFTELFCRA
IDNNMPLPTKEIDYKDDVLDVILNQRRLRNERMLSDRTNEIRSENLMDTTMDPPSSMNDA
LREVVEDETELFPPNLTRRYFLYFKPLSQNCARRYRKKAISSKPLSVRQIKGDFLGQLIT
VRGIITRVSDVKPAVEVIAYTCDQCGYEVFQEVNSRTFTPLSECTSEECSQNQTKGQLFM
STRASKFSAFQECKIQELSQQVPVGHIPRSLNIHVNGTLVRSLSPGDIVDVTGIFLPAPY
TGFKALKAGLLTETYLEAQFVRQHKKKFASFSLTSDVEERVMELITSGDVYNRLAKSIAP
EIYGNLDVKKALLLLLVGGVDKRVGDGMKIRGDINVCLMGDPGVAKSQLLKAICKISPRG
VYTTGKGSSGVGLTAAVMKDPVTDEMILEGGALVLADNGICCIDEFDKMDESDRTAIHEV
MEQQTISISKAGINTTLNARTSILAAANPLYGRYNPRLSPLDNINLPAALLSRFDILFLM
LDIPSRDDDEKLAEHVTYVHMHNKQPDLDFTPVEPSKMREYIAYAKTKRPVMSEAVNDYV
VQAYIRLRQDSKREMDSKFSFGQATPRTLLGIIRLSQALAKLRLADMVDIDDVEEALRLV
RVSKESLYQETNKSKEDESPTTKIFTIIKKMLQETGKNTLSYENIVKTVRLRGFTMLQLS
NCIQEYSYLNVWHLINEGNTLKFVDDGTMDTDQEDSLVSTPKLAPQTTASANVSAQDSDI
DLQDA

Sequence of entity 7 (A), FASTA

>7PMN_7 DNA replication complex GINS protein PSF1 (chains A)
MYGDLGNKLVLEAKRTKQLYARSNQDVNLPMYHEDIIRNILKEVSNLRKNTEYLKEQQQL
GMLDDKVAKCQYFVTLLCMERNKRCLLAYQRLRTDILDSMAWNNNGLDLMSSITFSQQDT
NNLSHQEQEYLKEYCDLITDLKSGDLVDIDLSGSLVPPSDVFIDVRVLKDAGEIQTEYGV
FNLIKDSQFFVRQSDVERLIQQGYLQKI

Sequence of entity 8 (B), FASTA

>7PMN_8 DNA replication complex GINS protein PSF2 (chains B)
MSLPAHLQQTFSPEEIQFIVENEPIKIFPRITTRQKIRGDDRGTGNHTRWQLITTDDKAL
NNMVAMRSTEVVLWIALLLKQQSKCSIVAPQWLTTKELDRKIQYEKTHPDRFSELPWNWL
VLARILFNKAKDDFHDPIHELRGKIQDLREIRQIKVLKGLKYLNESHLQLDNLSLLEINE
LRPFITEIMDKLREIHTASLTAGTENDEEEFNI

Sequence of entity 9 (C), FASTA

>7PMN_9 DNA replication complex GINS protein PSF3 (chains C)
MGYYDIDDVLADGTEFPCKFQYDIPGLGYLENNPGRPITKNTKLNLPLWLARILAIVGGD
EALVDEEPVPFVELLPPDMFSTKVMNAIKTDPVALDLHSINSHFFSLAIKWIMLFSEKEL
ANVVSELLLQRAQELNHHASSLSIDLNADSTGKNSANTNIATSTFLLKLEEMEKEIYKKS
HESYKDTKRWMFKK

Sequence of entity 10 (D), FASTA

>7PMN_10 DNA replication complex GINS protein SLD5 (chains D)
MDINIDDILAELDKETTAVDSTKITQGSSSTTHRDANTIVGSSLDLNDKTQIYVSPQQDF
SDLMKSWKNERCSPELLPYPHQLMKRLLNRISMQSQLIENISMGFLDMQNASNANPPMPN
ESKLPLLCMETELERLKFVIRSYIRCRLSKIDKFSLYLRQLNEDENSLISLTDLLSKDEI
KYHDTHSLIWLKLVNDSILKYMPEELQAINDTEGSVNMIDEPDWNKFVFIHVNGPPDGKW
NEDPLLQENEFGKPCYTVTIPDLKEEVELTIGSIYVMRYEVIRDLLRDDKVALI

Sequence of entity 11 (E), FASTA

>7PMN_11 Cell division control protein 45,Cell division control protein 45 (chains E)
MYYGISQFSEAYNKILRNSSSHSSCQLVIFVSCLNIDALCATKMLSLLFKKQLVQSQIVP
IFGYSELRRHYSQLDDNINSLLLVGFGGVIDLEAFLEIDPQEYVIDTDEKSGEQSFRRDI
YVLDAHRPWNLDNIFGSQIIQCFDDGTVDDTLGEQKEAYYKLLELDEESGDDELSGDEND
NNGGDDEATDADEVTDEDYKDDDGDYKDDDETISNKRGNSSIGPNDLSKRKQRKKQIHEY
EGVLEEYYSQGTTVVNSISAQIYSLLSAIGETNLSNLWLNILGTTSLDIAYAQVYNRLYP
LLQDEVKRLTPSSRNSVKTPDTLTLNIQPDYYLFLLRHSSLYDSFYYSNYVNAKLSLWNE
NGKKRLHKMFARMGIPLSTAQETWLYMDHSIKRELGIIFDKNLDRYGLQDIIRDGFVRTL
GYRGSISASEFVEALTALLEVGNSTDKDSVKINNDNNDDTDGEEEEDNSAQKLTNLRKRW
VSNFWLSWDALDDRKVELLNRGIQLAQDLQRAIFNTGVAILEKKLIKHLRIYRLCVLQDG
PDLDLYRNPLTLLRLGNWLIECCAESEDKQLLPMVLASIDENTDTYLVAGLTPRYPRGLD
TIHTKKPILNNFSMAFQQITAETDAKVRIDNFESSIIEIRREDLSPFLEKLTLSGLL

Sequence of entity 12 (F, G, H), FASTA

>7PMN_12 DNA polymerase alpha-binding protein (chains F, G, H)
MKRRWKKNFIAVSAANRFKKISSSGALENLYFQGEMVSVIDKLVFDFGGKTLVSLAPDNN
TLCVANKNGLTKILKTNNPEEEPETLDSSKLVSSIKCYSNSHFLMTTMQGDALRYNIDSS
QEELLARFALPLRDCCVIHSGKMAVFGGDDLELILLELDDETHKKHAIKIDEQVSQISYN
SQMNILAVSMINGKVQIFSLTSTIPNKVHELNDYIVANSYDDTHRDKILSNMMDDIDKDN
DNDLSETADPDENNVADPEFCAANRICTRVAWHPKGLHFALPCADDTVKIFSIKGYSLQK
TLSTNLSSTKAHFIDLQFDPLRGTYIAAVDLNNKLTVWNWETSEIHYTREFKRKITNIAW
KIQADSKTLDLVLGTWSGSIAIVQNLAESVVSNIPDQSVAESSTKHGLFVDSESDLENLE
GNDDINKSDKLFSDITQEANAEDVFTQTHDGPSGLSEKRKYNFEDEEDFIDDDDGAGYIS
GKKPHNEHSYSRVHKTHSFPISLANTGKFRYMPFSPAGTPFGFTDRRYLTMNEVGYVSTV
KNSEQYSITVSFFDVGRFREYHFEDLFGYDLCFLNEKGTLFGQSKTGQIQYRPHDSIHSN
WTKIIPLQAGERITSVAATPVRVIVGTSLGYFRSFNQFGVPFAVEKTSPIVALTAQNYRV
FSVHYSQFHGLSYSLSELGTSSKRYYKRECPLPMSLPNINSDMKKDANLDYYNFNPMGIK
SLFFSSYGDPCIFGSDNTLLLLSKWRSPEESKWLPILDSNMEIWKMSGGKETTDIHVWPL
ALAYDTLNCILVKGKHIWPEFPLPLPSEMEIRMPVFVKSKLLEENKAILNKKNEIGADTE
AEEGEEDKEIQIPVSMAAEEEYLRSKVLSELLTDTLENDGEMYGNENEVLAALNGAYDKA
LLRLFASACSDQNVEKALSLAHELKQDRALTAAVKISERAELPSLVKKINNIREARYEQQ
LK

Ligands and cofactors

ID	Name	Formula	Copies
ANP	Phosphoaminophosphonic acid-adenylate ester	C10 H17 N6 O12 P3	2
MG	Magnesium ion	Mg	2
ZN	Zinc ion	Zn	7

Primary citation

A conserved mechanism for regulating replisome disassembly in eukaryotes. Jenkyn-Bedford, M., Jones, M.L., Baris, Y. et al. Nature (2021) 600:743-747. DOI 10.1038/s41586-021-04145-3 · PubMed

Other PDB entries of the same protein (UniProt P29469 (AlphaFold model), which also has an AlphaFold model), best resolution first:

7W8G 2.52 Å, Cryo-EM structure of MCM double hexamer
28VY 2.7 Å, sCMGE assembled on ARS1 DNA with Sld2 and RPA
8RIF 2.79 Å, Cryo-EM structure of the MCM double hexamer loaded onto dsDNA.
7V3V 2.9 Å, Cryo-EM structure of MCM double hexamer bound with DDK in State I
9TH8 2.9 Å, Cryo-EM structure of MCM2-7 DH bound to Sld3-Sld7, Cdc45 and DNA
7P30 3.0 Å, 3.0 A resolution structure of a DNA-loaded MCM double hexamer
8KG6 3.07 Å, Yeast replisome in state I
9RHL 3.1 Å, Phospho-DH bound by Sld3-MBD on ARS1 DNA
7PMK 3.2 Å, S. cerevisiae replisome-SCF(Dia2) complex bound to double-stranded DNA (conformation I)
7PT6 3.2 Å, Structure of MCM2-7 DH complexed with Cdc7-Dbf4 in the presence of ATPgS, state III
7V3U 3.2 Å, Cryo-EM structure of MCM double hexamer with structured Mcm4-NSD
9E2Y 3.2 Å, Cryo-EM structure of yeast CMG helicase stalled at G4-containing DNA template, state 3

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