Ubiquitin-conjugating enzyme E2 13 (UBC13) is a 153-residue protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c). This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P52490.
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The mean pLDDT of this model is 94.5 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 94% |
| 70 to 90 | Confident: backbone generally right | 5% |
| 50 to 70 | Low: treat with caution | 1% |
| Below 50 | Very low: often disordered regions | 1% |
What pLDDT means and how to read it
Promotes the template-switching (TS) branch of the DNA damage tolerance (DDT) pathway (also known as the post-replication repair (PRR) pathway), that bypasses replication-blocking lesions without removing them (PubMed:25690888). Together with ubiquitin-protein ligase RAD5 and ubiquitin-conjugating enzyme MMS2, synthesizes 'Lys-63'-linked polyubiquitin chains on monoubiquitinated POL30/PCNA, to promote template-switching to the newly synthesized sister chromatid for error-free synthesis past the DNA lesion (PubMed:25690888)
Heterodimer with MMS2 (PubMed:10880451, PubMed:11440714). Interacts with RAD5; the interaction is direct and for POL30/PCNA polyubiquitination and to promote the error-free branch of the DNA damage tolerance (DDT) pathway (PubMed:11440714)
Cytoplasm, cytosol, Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 9GLT | X-ray | 1.45 Å | AAA/BBB=1-153 |
| 1JAT | X-ray | 1.6 Å | A=2-153 |
| 1JBB | X-ray | 2.0 Å | A/B=1-153 |
| 5OJW | X-ray | 2.0 Å | A=1-152 |
| 6ZHT | X-ray | 2.3 Å | B=1-152 |
| 6ZHS | X-ray | 2.35 Å | B/C=1-153 |
| 2GMI | X-ray | 2.5 Å | A=1-152 |
| 4FH1 | X-ray | 2.61 Å | A=1-153 |
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