Ubiquitin-conjugating enzyme variant MMS2 (MMS2) is a 137-residue protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c). This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P53152.
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The mean pLDDT of this model is 95.9 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 94% |
| 70 to 90 | Confident: backbone generally right | 5% |
| 50 to 70 | Low: treat with caution | 1% |
| Below 50 | Very low: often disordered regions | 0% |
What pLDDT means and how to read it
Promotes the template-switching (TS) branch of the DNA damage tolerance (DDT) pathway (also known as the post-replication repair (PRR) pathway), that bypasses replication-blocking lesions without removing them (PubMed:10880451). Together with ubiquitin-protein ligase RAD5 and ubiquitin-conjugating enzyme UBC13, synthesizes 'Lys-63'-linked polyubiquitin chains on monoubiquitinated POL30/PCNA, to promote template-switching to the newly synthesized sister chromatid for error-free synthesis past the DNA lesion (PubMed:10880451, PubMed:25690888)
Heterodimer with UBC13
Cytoplasm, cytosol, Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 1JAT | X-ray | 1.6 Å | B=1-137 |
| 5OJW | X-ray | 2.0 Å | B=1-137 |
| 2GMI | X-ray | 2.5 Å | B=1-137 |
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